Disruption of Gene Function Increases the Risk of Doxorubicin-Induced Cardiomyopathy and Heart Failure.

Doxorubicin is a cornerstone chemotherapeutic drug widely used to treat various cancers; its dose-dependent cardiomyopathy, however, is one of the leading causes of treatment-associated mortality in cancer survivors. Patients' threshold doses leading to doxorubicin-induced cardiomyopathy (DIC) and heart failure are highly variable, mostly due to genetic variations in individuals' genomes. However, genetic susceptibility to DIC remains largely unidentified.

Toward Evidence-Based Chinese Medicine: Status Quo, Opportunities and Challenges.

How to test the treatments of Chinese medicine (CM) and make them more widely accepted by practitioners of Western medicine and the international healthcare community is a major concern for practitioners and researchers of CM. For centuries, various approaches have been used to identify and measure the efficacy and safety of CM. However, the high-quality evidence related to CM that produced in China is still rare.

[Determination of endogenous amino acids in brain tissues after cerebral ischemia by RRLC-QQQ].

Objective: To establish a method to determine underivatized endogenous amino acids in brain tissues after cerebral ischemia based on RRLC-QQQ.

Method: Diamonsil chromatographic column C18 (4.6 mm x 250 mm, 5 microm) was adopted to determine 12 amino acids in 15 min, with acetonitrile-0.

[Study on safety and immunogenicity of group A/C meningococcal polysaccharide conjugate vaccine].

Objective: To evaluate the safety and immunogenicity of group A/C meningococcal polysaccharide conjugate vaccine.

Methods: The double-blind, randomized, parellel controlled, single central clinical trial was carried out to evaluat safety and immunogenicity of MCV-A/C.

Results: 4-fold rise rate of antibody to group A, C and A/C were more than 90 percent after MCV.

[Safety and immunogenicity of rabies vaccine (chick embryo cell) for human use produced in Germany and India].

Objective: To evaluate the safety and immunogenicity of Rabipur produced in India.

Methods: A random and single-blind study was conducted to compare the safety, effect and sero conversion rates. Rabipur produced in Germany used as control group.