Helicobacter pylori infection promotes M1 macrophage polarization and gastric inflammation by activation of NLRP3 inflammasome via TNF/TNFR1 axis.

Background: Macrophages play a crucial role in chronic gastritis induced by the pathogenic Helicobacter pylori (H. pylori) infection. NLRP3 inflammasome has emerged as an important component of inflammatory processes.

HPV genotypes in invasive cervical cancer: prevalence, risk attribution, and optimized vaccine strategies in western China.

Background: Understanding the HPV genotype distribution in invasive cervical cancer (ICC) is essential for vaccine optimization. This study presents a comprehensive analysis of HPV genotypes in ICC tissues from patients in western China, with the aim of informing regional vaccine policy and prevention strategies.

Methods: DNA was extracted from 1,908 paraffin-embedded ICC samples, and 23 HPV genotypes were detected via PCR and reverse dot hybridization gene chip assays.

Uniformly dispersing SbSe nanoparticles in porous carbon as an anode material for enhancing sodium storage capacity.

About 60 nm SbSe nanoparticles are uniformly embedded in a porous carbon substrate to prepare a SbSe/C composite through a combination of pyrolysis reduction and solid-phase selenization. The SbSe/C anode exhibits excellent sodium storage capacity. The initial discharge capacity is up to 420 mA h g at 0.

User-friendly prognostic model for rectal neuroendocrine tumours: In the era of precision management.

In this letter, we explore into the potential role of the recent study by Zeng . Rectal neuroendocrine tumours (rNETs) are rare, originate from peptidergic neurons and neuroendocrine cells, and express corresponding markers. Although most rNETs patients have a favourable prognosis, the median survival period significantly decreases when high-risk factors, such as larger tumours, poorer differentiation, and lymph node metastasis exist, are present.

Modulation of host N6-methyladenosine modification by gut microbiota in colorectal cancer.

As a research hotspot in the field of molecular biology, N6-methyladenosine (m6A) modification has made progress in the treatment of colorectal cancer (CRC), leukemia and other cancers. Numerous studies have demonstrated that the tumour microenvironment (TME) regulates the level of m6A modification in the host and activates a series of complex epigenetic signalling pathways through interactions with CRC cells, thus affecting the progression and prognosis of CRC. However, with the diversity in the composition of TME factors, this action is reciprocal and complex.

Advanced glycation end products in gastric cancer: A promising future.

In this editorial, we delve into the article and offer valuable insights into a crucial aspect of gastric cancer aetiology. Gastric cancer is a malignancy emanating from the epithelial lining of the gastric mucosa and one of the most prevalent forms of cancer worldwide. The development of gastric cancer is associated with multiple risk factors, including infection, advanced age, a diet rich in salt, and suboptimal eating patterns.

Elucidating the genotoxicity of Fusobacterium nucleatum-secreted mutagens in colorectal cancer carcinogenesis.

Background: Fusobacterium nucleatum (F. nucleatum) is one of the key tumorigenic bacteria in colorectal cancer (CRC), yet how F. nucleatum is involved in colorectal cancer carcinogenesis remains unknown.

Bipolar Textile Composite Electrodes Enabling Flexible Tandem Solid-State Lithium Metal Batteries.

A majority of flexible and wearable electronics require high operational voltage that is conventionally achieved by serial connection of battery unit cells using external wires. However, this inevitably decreases the energy density of the battery module and may cause additional safety hazards. Herein, a bipolar textile composite electrode (BTCE) that enables internal tandem-stacking configuration to yield high-voltage (6 to 12 V class) solid-state lithium metal batteries (SSLMBs) is reported.

UV-Permeable 3D Li Anodes for In Situ Fabrication of Interface-Gapless Flexible Solid-State Lithium Metal Batteries.

Flexible solid-state lithium metal batteries (SSLMBs) are highly desirable for future wearable electronics because of their high energy density and safety. However, flexible SSLMBs face serious challenges not only in regulating the Li plating/stripping behaviors but also in enabling the mechanical flexibility of the cell. Both challenges are largely associated with the interfacial gaps between the solid electrolytes and the electrodes.

Utility of gadoxetate disodium-enhanced magnetic resonance imaging in evaluating liver failure risk after major hepatic resection.

Background: Post-hepatectomy liver failure (PHLF) is still a predominant cause of hepatectomy-related mortality. However, it is difficult to evaluate the remnant liver functional reserve accurately before surgery to prevent PHLF. In this study, we aimed to explore the role of gadoxetate disodium-enhanced magnetic resonance imaging (MRI) in evaluating remnant liver functional reserve.

Bibliometric analysis and evaluation of publications on non- from 1993 to 2023.

A bibliometric analysis and evaluation of research on non- species (NHPHs) is essential to determining future research directions. A comprehensive search was carried out using predetermined search terms within the Web of Science Core Collection (WoSCC) to gather publications spanning from 1993 to 2023. VOSviewer and Citespace were employed for data analysis and visualization.

A Freestanding, Dissolution- and Diffusion-Limiting, Flexible Sulfur Electrode Enables High Specific Capacity at High Mass Loading.

The acquisition of stable and high-areal-capacity S cathodes over 10 mA h cm is a critical and indispensable step to realize the high energy density configuration. However, increasing the areal capacity of S cathodes often deteriorates the specific capacity and stability due to the aggravated dissolution of S and diffusion of solvable polysulfides in the thick electrode. Herein, the design of a freestanding composite cathode that leverages 3D covalent binding sites and chemical adsorption environment to offer dissolution-limiting and diffusion-blocking functions of S species is reported.

Metal-Organic Framework Based Mucoadhesive Nanodrugs for Multifunction Helicobacter Pylori Targeted Eradication, Inflammation Regulation and Gut Flora Protection.

The prevalence of drug-resistant bacteria presents a significant challenge to the antibiotic treatment of Helicobacter pylori (H. pylori), while traditional antimicrobial agents often suffer from shortcomings such as poor gastric retention, inadequate alleviation of inflammation, and significant adverse effects on the gut microbiota. Here, a selenized chitosan (CS-Se) modified bismuth-based metal-organic framework (Bi-MOF@CS-Se) nanodrug is reported that can target mucin through the charge interaction of the outer CS-Se layer to achieve mucosal adhesion and gastric retention.

ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastric tumor genesis and progression.

Helicobacter pylori (H. pylori) is a major risk factor of gastric cancer (GC). The SUMO-activating enzyme SAE1(SUMO-activating enzyme subunit 1), which is indispensable for protein SUMOylation, involves in human tumorigenesis.

LOX-1 acts as an N-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase.

The role of N-methyladenosine (mA) modification of host mRNA during bacterial infection is unclear. Here, we show that Helicobacter pylori infection upregulates host mA methylases and increases mA levels in gastric epithelial cells. Reducing mA methylase activity via hemizygotic deletion of methylase-encoding gene Mettl3 in mice, or via small interfering RNAs targeting mA methylases, enhances H.

Bilibili, TikTok, and YouTube as sources of information on gastric cancer: assessment and analysis of the content and quality.

Background: Gastric cancer has attracted widespread attention on social media due to its high incidence and severity. The Bilibili, TikTok, and YouTube video-sharing platforms have received considerable interest among general health consumers. Nevertheless, it remains unclear whether the information in videos on these platforms is of satisfactory content and quality.