Publications by authors named "Chuan Jie Zhou"
Effects of a Macroporous Resin Extract of Leaves in Rats with Hyperuricemia Induced by Anthropomorphic Unhealthy Lifestyle.
Evid Based Complement Alternat Med
January 2023
Article Synopsis
- The study investigates the effects of a macroporous resin extract of leaves (DoMRE) on reducing serum uric acid (SUA) levels in rats with hyperuricemia (HUA) induced by unhealthy lifestyle choices.
- Rats were given daily doses of DoMRE for 12 weeks, and various biochemical markers were measured to assess its impact on uric acid metabolism and liver function.
- Results showed that DoMRE significantly lowered SUA levels, increased fecal uric acid excretion, and regulated various enzymes and transporters related to uric acid processing in the body.
Background: The bursa of Fabricius (BF) is an acknowledged central immune organ, and is important to B cell differentiation. Bursal hexapeptide (BHP) is the recently reported bursalderived peptide, while its inducing function on immune response is uncertain.
Objectives: The main objective of this study was to analyze the immune responses to JEV vaccine in mice induced by BHP plus JEV vaccine, and to detect the signal and biological functions of BHP on immature B cells.
Background: Understanding the regulatory functions of the biological peptide from the humoral central immune organ bursa of Fabricius on vaccine immune responses and antibody production is of vital importance.
Objectives: Here we thoroughly verified the immunomodulatory functions of the new tetrapeptide BP4 from the bursa of Fabricius on vaccine immune responses in mice and chicken immunizaiton model, and on potential intracellular signaling during antibody production.
Method: BP4 was isolated and identified by Reverse Phase High Performance Liquid Chromatography and matrix-assisted laser desorption ionization time of flight mass spectrometry.