Publications by authors named "Chua J"

Aims: This study aims to identify factors associated with mental health literacy (mental health knowledge and attitudes towards mental health and help-seeking behaviours), depression and anxiety amongst adolescents, and test the hypothesised model by examining the interrelationships between these outcomes.

Design: Cross-sectional descriptive quantitative research.

Methods: Using convenient sampling, 615 adolescents from four public schools completed online questionnaires measuring mental health literacy, depression, and anxiety.

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  • Accurate diagnosis of Alzheimer's disease and vascular dementia is vital for timely treatment and better patient outcomes; this study focused on plasma and retinal biomarkers for differentiation among cognitive impairment groups.
  • The study involved 509 participants aged 50 and older, categorized into groups based on cognitive function using clinical assessments, neuropsychological tests, and MRI scans.
  • The findings revealed that both retinal layer thickness and plasma biomarker levels varied significantly across cognitive impairment levels, with decreases seen in retinal thickness and increases in plasma biomarkers from normal cognition to dementia.
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Background: Dementia poses a significant burden on healthcare systems. Early identification of individuals at risk for cognitive decline is crucial. The retina, an extension of the central nervous system, reflects neurodegenerative changes.

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Adolescents are susceptible to developing depression and anxiety, and educational interventions could improve their mental well-being. This systematic review aimed to evaluate the effectiveness of universal educational prevention interventions in improving mental health literacy, depression, and anxiety among adolescents. Eight electronic databases were searched until June 2024: Cochrane Library, PubMed, EMBASE, CINAHL, PsycINFO, Scopus, Web of Science, ProQuest Dissertations, and Theses Global.

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Significance: A data-based calibration method with enhanced depolarization contrast in polarization-sensitive optical coherence tomography (PS-OCT) was developed and demonstrated effective for detecting melanin content in the eye.

Aim: We aim to mitigate the dependence between the measured depolarization metric and the intensity signal-to-noise ratio (SNR) for improved visualization of depolarizing tissues, especially in low SNR regions, and to demonstrate the enhanced depolarization contrast to evaluate melanin presence.

Approach: A function for calibrating the depolarization metric was experimentally derived from the young albino guinea pig, assuming depolarization free in the retina.

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Background: Stage I nonsmall cell lung cancer (NSCLC) is primarily treated with surgical resection and has a favorable prognosis with an expected recurrence rate of 30%. New methods to risk stratify patients with stage I NSCLC are needed to help select those that might benefit from more active surveillance or adjuvant therapy.

Methods: We analyzed clinical data from 1330 patients (1469 tumors) with NSCLC and correlated it with next-generation sequencing (NGS).

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  • Mental health disorders are prevalent in the Philippines, prompting a study on how sociodemographic factors and spirituality affect depression, anxiety, and stress among emerging adults in Metro Manila.
  • The study utilized various questionnaires to collect data, revealing that a significant portion of participants experienced anxiety and depression, with notable associations to being LGBTQ+ and feelings of security.
  • The results indicate the need for tailored mental health programs that specifically address the challenges faced by LGBTQ+ individuals and promote a sense of security to improve overall mental well-being.
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Several validated image sets, such as NAPS, IAPS, GAPED, and OASIS, have been developed to elicit affective states. However, these image sets were primarily validated on Western populations within European and American contexts, and none have been fully validated in a Southeast Asian sample, where emotional restraint may also be valued similarly to the East Asian contexts. This study aimed to validate and provide norms for the Nencki Affective Picture System (NAPS; Marchewka et al.

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Background: Hospitalization often induces anxiety and fear in children, which may lead to maladaptive behaviours. Prior research has found that storytelling can help improve children's communication and reduce their stress. Not only does it enhance children's ability to express their emotions more effectively and comfortably, it also assists them in releasing negative emotions like anxiousness and fear.

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Purpose: To develop a quantitative tool for assessing the posterior ocular shape using widefield, volumetric optical coherence tomography (OCT) in eyes with myopia.

Methods: This observational, cross-sectional study included 178 eyes from 113 participants. Participants underwent a standardized eye examination, including ocular biometry and a custom ultrawide OCT.

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This study evaluated the performance of a customised Sensititre YeastOne (SYO) plate including isavuconazole (YIT) against existing practice (comprising SYO YO10 plate and isavuconazole gradient strip) in order to streamline the workflow for antifungal susceptibility testing in a tertiary hospital in Singapore. A total of 101 (51 yeasts and 50 moulds) clinical isolates were included for analysis. Isolates included in the study were recovered from a variety of body sites and reflected the case mix encountered in daily practice.

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Objective: Rehabilitation is thought to reduce ataxia severity in individuals with hereditary cerebellar ataxia (HCA). This multicenter, randomized controlled superiority trial aimed to examine the efficacy of a 30-week goal-directed rehabilitation program compared with 30 weeks of standard care on function, ataxia, health-related quality of life, and balance in individuals with an HCA.

Methods: Individuals with an autosomal dominant or recessive ataxia (aged ≥15 years) were enrolled at 5 sites in Australia.

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Background: This qualitative study aimed to explore the factors affecting job performance amongst junior doctors working for public healthcare institutions in Singapore. Within these institutions, junior doctors experience challenges with maintaining a balance in job demands and resources, leading to strain. Exploring the lived experiences of these junior doctors is essential when reviewing workplace and organizational factors that contribute to stress on an individual level, providing valuable insights to address these challenges effectively.

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Background: Universal community engagement interventions can address childhood obesity.

Objectives: This review aimed to evaluate the effectiveness of these interventions in improving body mass index (BMI) (primary outcome) as well as dietary choices and activity levels (secondary outcomes) among children and adolescents.

Methods: Eight electronic databases were searched from inception dates to January 2024.

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This study investigated various strategies: mono-, simultaneous and sequential fermentation of halophilic Candida versatilis and Tetragenococcus halophilus to valorize salted whey, a side stream of salted tofu (pressed beancurd) production, with an ultimate goal of creating a soy sauce-like condiment. Growth, glucose, organic acids were monitored throughout fermentation, while free amino acids and volatile compounds were analyzed on the final days. In monoculture fermentation, both C.

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  • Chronic musculoskeletal pain (CMP) and mental health issues affect young people, but their experiences and care preferences are not well understood. A systematic review analyzed these factors through qualitative studies involving individuals aged 16 to 24.
  • The review identified several key themes related to lived experiences, including the reciprocal relationship between CMP and mental health, psychosocial impacts, uncertainties about the future, and coping strategies.
  • It also highlighted care experiences such as navigating healthcare systems, the need for appropriate care, and care preferences, pointing out that services for CMP and mental health often lack integration and do not adequately support young people's needs.
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  • - Following a mild traumatic brain injury (mTBI), physiotherapists play a crucial role in identifying, assessing, and rehabilitating patients; however, their effectiveness and how patients perceive their role is not completely understood.
  • - In-depth interviews were conducted with 12 patients (ages 19-67) who previously received physiotherapy for mTBI in New Zealand, resulting in four major themes highlighting their experiences: effective delivery of care, empowerment for self-management, maximizing treatment engagement, and understanding individual patient needs.
  • - Participants generally viewed physiotherapists as vital in helping manage symptoms like headaches and neck pain, but emphasized the importance of personalized care that resonates with their preferences and unique situations for more successful rehabilitation outcomes. *
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Purpose: To describe the long-term outcomes of phacotrabeculectomy from a tertiary glaucoma service in Singapore.

Design: Retrospective case series.

Methods: Seven hundred ninety-six eyes of 698 patients who underwent phacotrabeculectomy surgery at the Singapore National Eye Centre between 2005 and 2007 with a minimum follow-up of three years were included.

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Introduction Best-practice guidelines recommend that patients are followed-up to check if they have recovered following a mild traumatic brain injury (mTBI) and to refer to concussion services, if needed. However, in New Zealand, rates of follow-up are low and access to concussion services can be delayed. Aim We aimed to improve rates of follow-up and access to concussion services for mTBI patients aged ≥8 years by the implementation of a supported health pathway and test its success.

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  • - The study evaluates the effectiveness of the Parentbot, a digital healthcare assistant, in improving various outcomes for parents during the perinatal period, including parenting self-efficacy, stress, and mental health.
  • - Conducted with 118 heterosexual couples in Singapore, the research involved random assignment to either the intervention group (Parentbot plus standard care) or a control group (standard care only), with data collected at multiple points postpartum.
  • - Results showed that the intervention group reported higher parenting self-efficacy at one month postpartum and lower anxiety levels among mothers at three months postpartum compared to the control group.
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Objectives: To develop and validate a psychometrically sound self-reported Paternal involvement in Early InfAnCy ScalE (PEACE) for Asian fathers with infants aged 0-12 months old.

Methods: This study comprised of three phases: (1) Pilot test among 100 fathers, (2) Exploring and confirming the PEACE's multidimensional structure using exploratory factor analysis (EFA) (n = 200 fathers) and confirmatory factor analysis (CFA) (n = 200 fathers), and (3) Assessing one-month test-retest reliability of PEACE among 30 fathers. Data was collected from August 2022 to August 2023.

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Background: Many mothers experience poor psychological outcomes during their perinatal period. The presence of depression and anxiety has a significant adverse impact on the mother's health and the infant's development.

Aim: This review aimed to examine the effectiveness of peer support interventions in improving depression, anxiety, and perceived social support among mothers during the perinatal period.

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