Publications by authors named "Chu-Yi Tan"
Article Synopsis
- Endotoxemia can lead to systemic inflammatory response syndrome (SIRS), coagulation issues, and acute lung injury (ALI), driven by activation of key blood and vascular cells.
- The study investigated the role of P-selectin glycoprotein ligand 1 (PSGL-1) using a mouse model of endotoxemia induced by lipopolysaccharide (LPS), while also administering PSGL-1 antibodies.
- Results indicated that blocking PSGL-1 reduced platelet and leukocyte activity, lessened inflammation, improved survival rates, and mitigated lung damage in the endotoxemic mice, highlighting PSGL-1's significant contribution to these conditions.
