Publications by authors named "Chu-Ting Lee"
A Boron-Dependent Antibiotic Derived from a Calcium-Dependent Antibiotic.
Angew Chem Int Ed Engl
January 2024
Article Synopsis
- The rise of drug-resistant bacteria poses a significant threat to healthcare, highlighting the need for new antibiotics.
- Calcium-dependent antibiotics (CDAs) like laspartomycin C (LspC) show promise against infections, but their reliance on calcium limits their effectiveness.
- Researchers developed a synthetic LspC analogue called B1, which uses phenylboronic acid instead of calcium, maintaining antibacterial activity against resistant strains while paving the way for innovative antibiotic design.