Publications by authors named "Chu-Qi He"
Article Synopsis
- The study examined how low-dose-rate radiation impacts zebrafish neurodevelopment and the influence of miRNAs on this process.
- Zebrafish embryos were subjected to different levels of gamma-ray irradiation (0 mGy/h to 0.4 mGy/h), with results showing that 0.1 mGy/h led to normal development while 0.2 mGy/h and 0.4 mGy/h caused increased issues like malformations and higher mortality rates.
- Changes in miRNA expression correlated with radiation exposure levels, suggesting a threshold effect where low doses may have beneficial effects, but higher doses can be harmful, all regulated by miRNAs.
J Appl Toxicol
November 2020
Article Synopsis
- - Tri-ortho-cresyl phosphate (TOCP) is an organophosphorus ester linked to delayed neuropathy in sensitive species, but the mechanisms behind its neurotoxicity are not fully understood.
- - The study reveals that TOCP induces autophagy in neuroblastoma cells through the activation of protein kinase C alpha (PKCα), which enhances the expression of certain autophagic proteins like NBR1, LC3, and P62.
- - PKCα activation disrupts the ubiquitin-proteasome system, leading to reduced proteasome activity and increased accumulation of abnormal proteins, contributing to neurodegenerative conditions such as hyperphosphorylated tau proteins and impaired MAP 2 and NF-H
