Publications by Chu-Hsuan Tsai | LitMetric

Publications by authors named "Chu-Hsuan Tsai"

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Generation and characterization of avian single chain variable fragment against human Alpha-Enolase.

Chi-Hsin Lee Chu-Hsuan Tsai Sy-Jye Leu Ko-Jiunn Liu Wei-Chu Wang Bor-Yu Tsai Chen-Hsin Tsai

Int Immunopharmacol

July 2023

Article Synopsis

Human alpha-enolase (hEno1) is overexpressed in various cancers and linked to poor prognosis, making it a valuable biomarker and treatment target.
Polyclonal IgY antibodies from chickens immunized with hEno1 showed a strong immune response, and phage display technology created two libraries of antibody fragments with a high number of transformants.
Selected anti-hEno1 antibody fragments (scFvs) effectively bound to hEno1 on lung cancer cells and significantly inhibited their growth and migration, suggesting potential for cancer diagnostics and therapy.

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