Enhancing the Conversion Efficiency of Polyethylene to Methane through Codoping of Mn Atoms into Ru Centers and CeO Supports.

Chemical conversion has emerged as an effective approach for disposing waste plastics; however, the product diversity in traditional methods leads to pressing challenges in product separation and purification. As a pioneering advancement, the comprehensive transformation of waste plastics into CH presents an attractive prospect: directly yielding high-purity products. Significantly, CH is an important hydrogen carrier and an industrial feedstock.

Synthesis of Mo-Pt/CeO Dual Single-Atom Nanozyme for Multifunctional Biochemical Detection Applications.

Elaborated structural modulation of Pt-based artificial nanozymes can efficiently improve their catalytic activity and expand their applications in clinical diagnosis and biochemical sensing. Herein, a highly efficient dual-site peroxidase mimic composed of highly dispersed Pt and Mo atoms is reported. The obtained Mo-Pt/CeO exhibits exceptional peroxidase-like catalytic activity, with a V as high as 34.

Mass-Produced Skin-Inspired Piezoresistive Sensing Array with Interlocking Interface for Object Recognition.

E-skins, capable of responding to mechanical stimuli, hold significant potential in the field of robot haptics. However, it is a challenge to obtain e-skins with both high sensitivity and mechanical stability. Here, we present a bioinspired piezoresistive sensor with hierarchical structures based on polyaniline/polystyrene core-shell nanoparticles polymerized on air-laid paper.

Notch1 regulates hepatic thrombopoietin production.

Notch signaling regulates cell-fate decisions in several developmental processes and cell functions. However, the role of Notch in hepatic thrombopoietin (TPO) production remains unclear. We noted thrombocytopenia in mice with hepatic Notch1 deficiency and so investigated TPO production and other features of platelets in these mice.

Strengthening the Metal-Acid Interactions by Using CeO as Regulators of Precisely Placing Pt Species in ZSM-5 for Furfural Hydrogenation.

Understanding the synergism between the metal site and acid site is of great significance in boosting the efficiency of bi-functional catalysts in many heterogeneous reactions, particularly in biomass upgrading. Herein, a "confined auto-redox" strategy is reported to fix CeO-anchored Pt atoms on the inner wall of a ZSM-5 cage, achieving the target of finely controlling the placements of the two active sites. Compared with the conventional surface-supported counterpart, the encapsulated Pt/CeO@ZSM-5 catalyst possesses remarkably-improved activity and selectivity, which can convert >99% furfural into cyclopentanone with 97.

Investigating neuropathological changes and underlying neurobiological mechanisms in the early stages of primary blast-induced traumatic brain injury: Insights from a rat model.

The utilization of explosives and chemicals has resulted in a rise in blast-induced traumatic brain injury (bTBI) in recent times. However, there is a dearth of diagnostic biomarkers and therapeutic targets for bTBI due to a limited understanding of biological mechanisms, particularly in the early stages. The objective of this study was to examine the early neuropathological characteristics and underlying biological mechanisms of primary bTBI.

Metal-based nanoparticles in antibacterial application in biomedical field: Current development and potential mechanisms.

The rise in drug resistance in pathogenic bacteria greatly endangers public health in the post-antibiotic era, and drug-resistant bacteria currently pose a great challenge not only to the community but also to clinical procedures, including surgery, stent implantation, organ transplantation, and other medical procedures involving any open wound and compromised human immunity. Biofilm-associated drug failure, as well as rapid resistance to last-resort antibiotics, necessitates the search for novel treatments against bacterial infection. In recent years, the flourishing development of nanotechnology has provided new insights for exploiting promising alternative therapeutics for drug-resistant bacteria.

Platelet-Derived TGF-β1 Promotes Deep Vein Thrombosis.

Background:  Transforming growth factor-β1 (TGF-β1) modulates multiple cellular functions during development and tissue homeostasis. A large amount of TGF-β1 is stored in platelet α-granules and released upon platelet activation. Whether platelet-derived TGF-β1 plays a role in venous thrombosis remains unclear.

Celastrol inhibits platelet function and thrombus formation.

Introduction: Celastrol is an active pentacyclic triterpenoid extracted from Tripterygium wilfordii and has anti-inflammatory and anti-tumor properties. Whether Celastrol modulates platelet function remains unknown. Our study investigated its role in platelet function and thrombosis.

Carbapenems β-lactam and β-lactamase inhibitors for treatment of nosocomial pneumonia: A systematic review and meta-analysis.

Background: Carbapenems and β-lactam and β-lactamase inhibitors (BLBLIs) have been used empirically in nosocomial pneumonia, but their efficacy and safety are controversial.

Objective: We carried out a systematic review with meta-analysis to evaluate the efficacy and safety of carbapenems versus BLBLIs against nosocomial pneumonia.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, CNKI, Wangfang, VIP and Sinomed were searched systematically through April 29, 2023 for clinical trials comparing carbapenems with BLBLIs for treatment of nosocomial pneumonia.

Dimethyl fumarate possesses antiplatelet and antithrombotic properties.

Background: Dimethyl fumarate (DMF) is a methyl ester of fumaric acid and has been approved for treating multiple sclerosis (MS) and psoriasis due to anti-inflammatory effect. There is a close association between platelets and the pathogenesis of MS. Whether DMF affects platelet function remains unclear.

Vertical-MXene based micro-supercapacitors with thickness-independent capacitance.

MXenes have shown great potential as an emerging two-dimensional (2D) material for micro-supercapacitors (MSCs) due to their high conductivity, rich surface chemistry, and high capacity. However, MXene sheets inherently tend to lay flat on the substrate during film formation to assemble into compact stacked structures, which hinders ion accessibility and prolongs ion transport paths, leading to highly dependent electrochemical properties on the thickness of the film. Here, we demonstrate a vertically aligned TiCT MXene based micro-supercapacitor with an excellent electrochemical performance by a liquid nitrogen-assisted freeze-drying method.

Recent advances in polyaniline-based micro-supercapacitors.

The rapid development of the Internet of Things (IoTs) and proliferation of wearable electronics have significantly stimulated the pursuit of distributed power supply systems that are small and light. Accordingly, micro-supercapacitors (MSCs) have recently attracted tremendous research interest due to their high power density, good energy density, long cycling life, and rapid charge/discharge rate delivered in a limited volume and area. As an emerging class of electrochemical energy storage devices, MSCs using polyaniline (PANI) electrodes are envisaged to bridge the gap between carbonaceous MSCs and micro-batteries, leading to a high power density together with improved energy density.

Incorporation of CeO with Ni-Co mixed metal phosphide boosts electrochemical seawater oxidation performance.

Electrochemical seawater oxidation has been regarded as one of the most promising strategies for cost-efficient production of hydrogen from the standpoint of sustainability, but suffers from a competitive chlorine evolution/oxidation reaction. Herein, we report a facile hard templated route to fabricate CeO incorporated Ni-Co mixed metal phosphide embedded in a carbon matrix (CeO-CoNiP@C). Benefiting from compositional and structural features, the obtained CeO-CoNiP@C possesses remarkably improved OER performance in 1 M KOH ( = 295 mV at 10 mA cm) compared with CoNiP@C.

Iodine-Ion-Assisted Galvanic Replacement Synthesis of Bismuth Nanotubes for Ultrafast and Ultrastable Sodium Storage.

Bismuth (Bi) has emerged as a promising anode material for fast-charging and long-cycling sodium-ion batteries (SIBs). However, its dramatically volumetric variations during cycling will undesirably cause the pulverization of active materials, severely limiting the electrochemical performance of Bi-based electrodes. Constructing hollow nanostructures is recognized as an effective way to resolve the volume expansion issues of alloy-type anodes but remains a great challenge for metallic bismuth.

The Host CYP1A1-Microbiota Metabolic Axis Promotes Gut Barrier Disruption in Methicillin-Resistant -Induced Abdominal Sepsis.

Background: Host-microbiota crosstalk has been implicated in multiple host metabolic pathway axes that regulate intestinal barrier function. Although constitutive cytochrome P4501A1 (CYP1A1) expression perturbs the microbiome-derived autoregulatory loop following enteric infection, little is known about the role of host CYP1A1 in modulating gut microbiome-mediated signaling during methicillin-resistant (MRSA)-induced abdominal sepsis and its effects on intestinal barrier integrity.

Methods: Abdominal sepsis was induced by the intraperitoneal injection of MRSA in mice.

TiCT MXene-Based Micro-Supercapacitors with Ultrahigh Volumetric Energy Density for All-in-One Si-Electronics.

MXene-based microsupercapacitors (MSCs) have promoted the development of on-chip energy storage for miniaturized and portable electronics due to the small size, high power density and integration density. However, restricted energy density and operating voltage invariably create obstacles to the practical application of MSCs. Here, we report a symmetric MXene-based on-chip MSC, achieving an ultrahigh energy density of 75 mWh cm with high operating voltage of 1.

Thermodynamics-Induced Injection Enhanced Deep-Blue Perovskite Quantum Dot LEDs.

Precisely tuning emission spectra through the component control of mixed halides has been proved to be an efficient method for procuring deep-blue perovskite LEDs (PeLEDs). However, the inferior color instability and lifetime attenuation, originated from vacancy- and trap-mediated mechanisms under an external field, remain an uninterruptedly formidable challenge for the commercial development of PeLEDs. Here, an ultrafast thermodynamics-induced injection enhancement strategy was employed to promote efficient carrier recombination within perovskite quantum dots (QDs), accompanied by less inefficient charge accumulation and trap generation, enabling deep-blue PeLEDs with improved thermal and spectral stability.

Hierarchically Microstructure-Bioinspired Flexible Piezoresistive Bioelectronics.

The naturally microstructure-bioinspired piezoresistive sensor for human-machine interaction and human health monitoring represents an attractive opportunity for wearable bioelectronics. However, due to the trade-off between sensitivity and linear detection range, obtaining piezoresistive sensors with both a wide pressure monitoring range and a high sensitivity is still a great challenge. Herein, we design a hierarchically microstructure-bioinspired flexible piezoresistive sensor consisting of a hierarchical polyaniline/polyvinylidene fluoride nanofiber (HPPNF) film sandwiched between two interlocking electrodes with microdome structure.

Air-Stable Conductive Polymer Ink for Printed Wearable Micro-Supercapacitors.

Printed electronics are expected to facilitate the widespread distributed wearable electronics in the era of the Internet of things. However, developing cheap and stable electrode inks remains a significant challenge in the printed electronics industry and academic community. Here, overcoming the weak hydrophilicity of polyaniline, a low-cost, easy-fabricating, and air-stable conducting polymer (CP) ink is devised through a facile assemble-disperse strategy delivering a high conductivity in the order of 10 S cm along with a remarkable specific capacitance of 386.

Manipulating Relative Permittivity for High-Performance Wearable Triboelectric Nanogenerators.

As the world marches into the era of the Internet of Things (IoT), the practice of human health care is on the cusp of a revolution, driven by an unprecedented level of personalization enabled by a variety of wearable bioelectronics. A sustainable and wearable energy solution is highly desired , but challenges still remain in its development. Here, we report a high-performance wearable electricity generation approach by manipulating the relative permittivity of a triboelectric nanogenerator (TENG).

Unraveling and Regulating Self-Discharge Behavior of TiCT MXene-Based Supercapacitors.

Rich chemistry and surface functionalization provide MXenes enhanced electrochemical activity yet severely exacerbate their self-discharge behavior in supercapacitors. However, this self-discharge behavior and its related mechanism are still remaining issues. Herein, we propose a chemically interface-tailored regulation strategy to successfully unravel and efficiently alleviate the self-discharge behavior of TiCT MXene-based supercapacitors.