Novel 4-aminoquinoline analogs targeting the HIF-1α signaling pathway.

The aminoquinoline core exhibits versatile pharmacological properties, particularly in the area of anticancer activity. This study was designed to investigate the potential of the 4-aminoquinoline scaffold in the development of anticancer agents by targeting the HIF-1α signaling pathway. The authors synthesized multiple derivatives of 4-aminoquinoline containing heterocyclic rings by a microwave reactor and assessed the cytotoxicity and inhibitory effects of these derivatives on the HIF-1α signaling pathway.

Selective oxidation of p-phenylenediamine for blood glucose detection enabled by Se-vacancy-rich TiSe@Au nanozyme.

Nanozymes with enzyme-like characteristics have drawn wide interest but the catalytic activity and substrate selectivity of nanozymes still need improvement. Herein, Se-vacancy-rich TiSe@Au nanocomposites are designed and demonstrated as nanozymes. The TiSe@Au nanocomposites show excellent peroxidase-like activity and the chromogenic substrate p-phenylenediamine (PPD) can be selectively oxidized to compounds that exhibit an absorption peak at 413 nm that differs from that of self-oxidation or generally oxidized species, suggesting high catalytic activity and strong substrate selectivity.

Ultra-broadband 3-dB coupler based on dual-hollow-core polymer fiber covering E + S + C + L + U band.

An ultra-broadband 3-dB coupler based on a polymer dual-hollow-core anti-resonant fiber (DHC-ARF) is designed to work in the E + S + C + L + U communication band. By incorporating two elliptical-like cores and modulating the air gap between the two cores, the wavelength and polarization dependence of the DHC-ARF-based coupler is reduced effectively. The feasibility of using a 1.

3D-printed high-birefringence THz hollow-core anti-resonant fiber with an elliptical core.

A high-birefringence and low-loss terahertz (THz) hollow-core anti-resonant fiber (THz HC-ARF) is designed and analyzed numerically by the finite element method (FEM). The THz HC-ARF is composed of an elliptical tube as the core for high birefringence guidance and a pair of symmetrical slabs arranged vertically as the cladding to attain low loss. Numerical analysis indicates that the birefringence reaches 10 in the transmission window between 0.

Double-ring-disk hybrid nanostructures with slits for electric field enhancement.

Although noble metal nanoantennas have distinctive optical properties and local electric field enhancement, considerable non-radiative ohmic losses occur at the optical frequencies, consequently creating significant absorption and unwanted heating. Combining the plasmon mode of metal nanoantennas with the anapole mode of high refractive index dielectric materials offers a promising alternative to increase the electric field strength with minimal loss. Herein, a silicon disk with slots and two Au rings with a coupling mechanism are described.

Effects of different cladding materials on orbital angular momentum modes propagating in photonic crystal fibers.

With the development of orbital angular momentum (OAM) photonic crystal fibers (PCFs) for more efficient communication, fiber claddings are important to the performance. In this paper, the influence of and four new optical materials, which are amethyst, SSK2, SF11, and LaSF09, as cladding materials, on the OAM mode characteristics is studied based on a common PCF for OAM transmission. In addition, the effective index difference, dispersion, confinement loss, and other properties of OAM modes transmitted in the five materials are derived by the finite element method.

Design of optical anapole modes of all-dielectric nanoantennas for SERS applications.

To obtain large electric field enhancement while mitigating material losses, an all-dielectric nanoantenna composed of a heptamer and nanocubes is designed and analyzed. A numerical simulation by the finite element method reveals that the nanoantenna achieves the optical electric anapole modes, thereby significantly enhancing the coupling between different dielectrics to further improve the near-field enhancement and spontaneous radiation. Field enhancement factors |/ | of 3,563 and 5,395 (AM1 and AM2) and a Purcell factor of 3,872 are observed in the wavelength range between 350 and 800 nm.

Surface plasmon resonance sensor composed of a D-type photonic crystal fiber with a three-layer coating.

A surface plasmon resonance sensor composed of photonic crystal fibers (PCF-SPR) with an - - triple layer is designed for refractive index (RI) sensing and analyzed theoretically by the finite element method. The sensor exhibits enhanced resonance coupling between the core mode and surface plasmon polariton (SPP) mode as well as better sensitivity than the structure with a single gold coating. Furthermore, the - - tri-layer structure narrows the linewidth of the loss spectrum and improves the figure of merit (FOM).

Remote Recruitment Strategy and Structured E-Parenting Support (STEPS) App: Feasibility and Usability Study.

Background: The Structured E-Parenting Support (STEPS) app provides support for parents of children with elevated hyperactivity, impulsivity, inattention, and conduct problems who are awaiting clinical assessment. STEPS will be evaluated in a randomized controlled trial (RCT) within the Online Parent Training for the Initial Management of ADHD Referrals (OPTIMA) research program in the United Kingdom. Phase 1 of the OPTIMA tested the feasibility of participants' recruitment and the app's usability.

Acute cold stress leads to zebrafish ovarian dysfunction by regulating miRNA and mRNA.

Temperature is a critical factor that regulates the reproduction processes in teleost. However, the gonadal response mechanism to cold stress in fish remains largely unknown. In the present study, female zebrafish were exposed to different extents of low temperatures at 18 °C and 10 °C for 48 h.

Association between urinary glyphosate levels and serum neurofilament light chain in a representative sample of US adults: NHANES 2013-2014.

Background: Glyphosate, the herbicide with the highest global usage, has been found to have links to neurological impairment in some occupational studies. Neurofilament light chain (NfL) is a protein that is released into the bloodstream following neuroaxonal damage and has emerged as a reliable biomarker for various neurological disorders. However, no research has investigated the potential link between glyphosate exposure and neurological damage or serum NfL levels in the general population.

Synthesis of germanium/germanium phosphide in-plane heterostructure with efficient photothermal and enhanced photodynamic effects in the second near-infrared biowindow.

Inspired by the bifunctional phototherapy agents (PTAs), constructing compact PTAs with efficient photothermal therapy (PTT) and photodynamic therapy (PDT) effects in the near-infrared (NIR-II) biowindow is crucial for high therapeutic efficacy. Herein, none-layered germanium (Ge) is transformed to layered Ge/germanium phosphide (Ge/GeP) structure, and a novel two-dimensional sheet-like compact S-scheme Ge/GeP in-plane heterostructure with a large extinction coefficient of 15.66 L/g cm at 1,064 nm is designed and demonstrated.

Outcomes of Endovascular Treatment for Infective Aortic Aneurysms - A Multicenter Retrospective Study.

Background: In Taiwan, infective native aortic aneurysms (INAAs) are relatively common, so the aim of present study was to demonstrate the comparative outcomes of endovascular repair for thoracic and abdominal INAAs.

Methods and results: Patients with naïve thoracic or abdominal INAAs managed with endovascular repair between 2001 and 2018 were included in this multicenter retrospective cohort. The confounding factors were adjusted with propensity score (PS).

CT acquisition parameter selection in the real world: impacts on radiation dose and variation amongst 155 institutions.

Objective: Quantify the relationship between CT acquisition parameters and radiation dose, how often parameters are adjusted in real-world practice, and their degree of contribution to real-world dose distribution. Identify discrepancies between parameters that are impactful in theory and impactful in practice.

Methods: This study analyses 1.

Associated radiation exposure from medical imaging and excess lifetime risk of developing cancer in pediatric patients with pulmonary hypertension.

Pediatric patients with pulmonary hypertension (PH) receive imaging studies that use ionizing radiation (radiation) such as computed tomography (CT) and cardiac catheterization to guide clinical care. Radiation exposure is associated with increased cancer risk. It is unknown how much radiation pediatric PH patients receive.

Cardiovascular and renal outcomes in patients with atrial fibrillation and stage 4-5 chronic kidney disease receiving direct oral anticoagulants: a multicenter retrospective cohort study.

The role of direct oral anticoagulants (DOAC) in patients with atrial fibrillation (AF) and stage 4-5 chronic kidney disease (CKD) is controversial. Electronic medical records from 2012 to 2021 were retrieved for patients with AF and stage 4-5 CKD receiving oral anticoagulants. Patients were separated into those receiving DOACs (dabigatran, rivaroxaban, apixaban, or edoxaban) or vitamin K antagonists (VKA).

Inner-Frame Time Division Multiplexing Waveform Design of Integrated Sensing and Communication in 5G NR System.

The design of an integrated sensing and communication (ISAC) waveform compatible with the 5G new radio (NR) system is crucial in enabling ISAC by utilizing the hardware of existing base stations (BSs). In this paper, we design an inner-frame time division multiplexed sensing waveform in the frame structure of 5G NR to achieve ISAC. The designed waveform is computed by the simulated annealing algorithm on an optimization cost function of a constrained combination of the peak-to-sidelobe ratio (PSLR) and the integrated sidelobe ratio (ISLR) of the velocity ambiguity function.

MAP7D3, a novel prognostic marker for triple-negative breast cancer, drives cell invasiveness and cancer-initiating cell properties to promote metastatic progression.

Background: Patients with triple-negative breast cancer (TNBC) tend to develop visceral metastasis within five years, making them the most challenging BC patients to treat. The MAP7 protein family is a group of microtubule-binding proteins with a well-known role in microtubule-related cell migration, but its role in metastasis-related properties of TNBC remains unclear.

Methods: qRT-PCR and western blot were used to validate mRNA and protein expression of the MAP7 family in the isogenic pairs of TNBC cell lines with low and high metastasis potential.

The impact of shoulder pathologies on job discontinuation and return to work: a pilot ultrasonographic investigation.

Background: Ultrasound imaging has emerged as one of the most useful tools for evaluating shoulder disorders. To date, the association between shoulder ultrasonography and a patient's work status has rarely been explored by antecedent studies.

Aim: This study aimed to investigate the association between sonographically diagnosed shoulder pathologies and job discontinuation and return to work.

Case report: Open-heart removal for a cement embolism formed 10 years ago in the right ventricle and pulmonary artery.

Bone cement embolism is a known complication after a kyphoplasty operation. Cement embolisms without immediate fatal complication such as cardiac perforation or hypoxemia were often stable during observation. We report a case of a large volume bone cement embolism involving the right ventricle and the pulmonary artery system.

Interfacial Engineering Enables Perovskite Heteroepitaxial Growth on Black Phosphorus for Flexible X-ray Detectors.

2D materials with atomic-scale thickness and mechanical robustness are required for flexible devices. The superior optoelectronic properties and high-Z atoms in metal halide perovskites render them desirable for X-ray detection, but the intrinsic brittleness is an obstacle hampering the applications in flexible detectors. Herein, an interfacial engineering strategy is demonstrated for the epitaxial growth of methylammonium lead bromide (MAPbBr ) on black phosphorus (BP) for flexible X-ray detectors.