The tumor microenvironment in gastrointestinal adenocarcinomas revealed a prognostic and immunotherapeutic biomarker.

Accumulated evidence has elucidated that the tumor microenvironment (TME) is great of clinical significance in predicting survival outcomes and therapeutic efficacy. Nonetheless, few studies have investigated the prognostic and immunotherapeutic signature correlated with TME phenotypes in gastrointestinal adenocarcinomas (GIAC). Here, by estimating the TME pattern of immune infiltration and expression in over 1,000 GIAC patients, we revealed three TME subgroups and identified six key differential genes.

Up-Regulation of SH3TC2 Induced by YTHDF1 Predicts Poor Outcome and Facilitates Cell-Cycle Progress in Colorectal Cancer.

N6-methyladenosine (m6A) modification plays a crucial role in determining the fate and function of RNA transcripts in tumor cells. Nevertheless, how m6A regulates the expression of key molecules and coordinates its involvement in the development of colorectal cancer (CRC) remains largely unclear. Here, we report that the m6A reading protein YTHDF1-mediated up-regulation of SH3TC2 promotes CRC growth both in vitro and in vivo.

Catalyst-Free Oxidation Reactions in a Microwave Plasma Torch-Based Ion/Molecular Reactor: An Approach for Predicting the Atmospheric Oxidation of Pollutants.

The atmospheric oxidation of chemicals has produced many new unpredicted pollutants. A microwave plasma torch-based ion/molecular reactor (MPTIR) interfacing an online mass spectrometer has been developed for creating and monitoring rapid oxidation reactions. Oxygen in the air is activated by the plasma into highly reactive oxygen radicals, thereby achieving oxidation of thioethers, alcohols, and various environmental pollutants on a millisecond scale without the addition of external oxidants or catalysts (6 orders of magnitude faster than bulk).

Salt-templated porous melamine-based conjugated polymers for selective oxidation of amines into imines under visible light.

Conjugated polymers have a broad application foreground in the field of photocatalytic organic synthesis to produce value-added chemicals due to their functional diversity, broad light responsive ability, high thermal and chemical stability, and tunable band structure. Herein, using mixed chloride salts (i.e.

Utilization of different wood-based microfibril cellulose for the preparation of reinforced hydrophobic polymer composite films via Pickering emulsion: A comparative study.

Pickering emulsion is a promising strategy for the preparation of hydrophobic polymer composite using hydrophilic nanocellulose. Herein, two types of microfibril cellulose, pure mechanical pretreated microfibril cellulose (P-MFC) and Deep eutectic solvents pretreated microfibril cellulose (DES-MFC), were used to fabricate reinforced hydrophobic polystyrene (PS) composites (MFC/PS) with the aid of Pickering emulsion. The results showed that both oil/water ratio and the content as well as surface hydrophilicity of MFC were playing an important role in emulsifying capacity.

Skin-mimicking strategy to fabricate strong and highly conductive anti-freezing cellulose-based hydrogels as strain sensors.

Conductive hydrogels have attracted increasing attention for applications in wearable and flexible strain sensors. However, owing to their relatively weak strength, poor elasticity, and lack of anti-freezing ability, their applications have been limited. Herein, we present a skin-mimicking strategy to fabricate cellulose-enhanced, strong, elastic, highly conductive, and anti-freezing hydrogels.

Superhydrophobic Strategy for Nature-Inspired Rotating Microfliers: Enhancing Spreading, Reducing Contact Time, and Weakening Impact Force of Raindrops.

Wind-dispersal of seeds is a remarkable strategy in nature, enlightening the construction of microfliers for environmental monitoring. However, the flight of these microfliers is greatly affected by climatic conditions, especially in rainy days, they suffer serious raindrop impact. Here, a hierarchical superhydrophobic surface is fabricated and a novel strategy is demonstrated that the superhydrophobic coating can enhance spreading while reduce contact time and impact force of raindrops, all of which are beneficial for the rotating microfliers.

The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease.

Background: Perirenal fat (PRF) has multiple effects on the kidney through its physical structure and adipocytokine-secreting ability. The present study explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes.

Methods: In the cross-sectional analysis, we screened 959 patients from 8764 subjects with type 2 diabetes mellitus (T2DM) who met the inclusion criteria and measured their perirenal fat thickness (PFT) using color Doppler ultrasound.

Anti-Inflammatory Activities of Constituents from Hayata Leaves and Their Mechanisms.

is an endemic species of Taiwan. Although most Cinnamomum plants have significant biological activity, the bioactivity investment of is rare. Since inflammation plays an important role in many diseases, anti-inflammatory compounds can be developed into healthcare products.

Residual choledocholithiasis after choledocholithotomy T-tube drainage: what is the best intervention strategy?

Background: The best intervention approach for residual choledocholithiasis after choledocholithotomy T-tube drainage remains controversial, especially during the period of indwelling T tube and the formation of a sinus. The purpose of the study was to estimate the effects of two therapeutic modalities, namely endoscopic retrograde cholangiopancreatography (ERCP) and choledochfiberscope via the T-tube sinus tract (CDS) on residual choledocholithiasis after choledocholithotomy T-tube drainage.

Methods: A total of 112 patients with residual choledocholithiasis after choledochotomy were included in the study, 50 of which underwent ERCP and 62 patients experienced choledochoscopy via the T-tube sinus tract.

BRCA-CRisk: A Contralateral Breast Cancer Risk Prediction Model for Carriers.

Purpose: The absolute cumulative risk of contralateral breast cancer (CBC) for patients with / variants is unknown. The purpose of this study was to develop a CBC risk prediction model for assessing CBC risk for / carriers.

Methods: The primary cohort of 491 patients with / variants was derived from a large series of unselected patients with breast cancer.

LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells.

Objectives: Lung cancer was one of the most common malignancies around the world. It has great significance in to search for the mechanism of occurrence and development of lung cancer. LIM Domain Binding protein 2 (LDB2) belongs to the LIM-domain binding family, it can be used as a binding protein that combined with other transcription factors to form the transcription complex for regulating the expression of target genes.

The role of O-GlcNAcylation in innate immunity and inflammation.

O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) is a highly dynamic and widespread post-translational modification (PTM) that regulates the activity, subcellular localization, and stability of target proteins. O-GlcNAcylation is a reversible PTM controlled by two cycling enzymes: O-linked N-acetylglucosamine transferase and O-GlcNAcase. Emerging evidence indicates that O-GlcNAcylation plays critical roles in innate immunity, inflammatory signaling, and cancer development.

Application of the combination of three-dimensional visualization with a problem-based learning mode of teaching to spinal surgery teaching.

Objective: To explore the application of the combination of three-dimensional visualization technology with a problem-based learning mode of teaching in clinical teaching related to spinal surgery.

Methods: A total of 106 5-year undergraduate students who majored in clinical medicine were selected as research subjects, and practiced in the Orthopaedics Department of the Affiliated Hospital of Xuzhou Medical University in 2021. These students were randomly divided into an experimental group and a control group, with 53 students in each group.

The impact of angiotensin converting enzyme insertion/deletion gene polymorphism on diabetic kidney disease: A debatable issue.

Objective: The objective of this study was to evaluate the influence of ACE I/D gene polymorphisms on diabetic kidney disease (DKD) risk.

Methods: All eligible investigations were identified, the number of various genotype in the case and control group were reviewed. The pooled analysis was performed using Stata software.

Biomimetic ultra-strong, ultra-tough, degradable cellulose-based composites for multi-stimuli responsive shape memory.

Fabrication of ultra-strong, ultra-tough, sustainable, and degradable bio-based composites is urgently needed but remains challenging. Here, a biomimetic sustainable, degradable, and multi-stimuli responsive cellulose/PCL/FeO composite with ultra-strong mechanical strength and ultra-high toughness was developed. To prepare the proposed composites, the soft poly(ε-caprolactone) (PCL) side chain was grafted onto the rigid cellulose backbone, then the cellulose graft copolymer (EC-g-PCL) reacted with rigid hexamethylenediamine modified FeO nanoparticle (FeO-NH) to construct the crosslinking network using MDI-50 as a crosslinker.

Accurate delivery of pristimerin and paclitaxel by folic acid-linked nano-micelles for enhancing chemosensitivity in cancer therapy.

Chemoresistance remains a huge challenge for effective treatment of non-small cell lung cancer (NSCLC). Previous studies have shown Chinese herbal extracts possess great potential in ameliorating tumor chemoresistance, however, the efficacy is clinically limited mainly because of the poor tumor-targeting and in vivo stability. The construction of nano-delivery systems for herbal extracts has been shown to improve drug targeting, enhance therapeutic efficacy and reduce toxic and side effects.

LPA maintains innate antiviral immunity in a pro-active state via STK38L-mediated IRF3 Ser303 phosphorylation.

Innate immunity is critical for the early detection and elimination of viral invasion. Extracellular signals are crucial for host resistance; however, how extracellular factors prepare the innate immunity for rapid antiviral response remains elusive. Here, we find that serum deprivation largely restricts the innate antiviral responses to RNA and DNA viruses.

Strain-Tunable Electronic and Transport Properties of One-Dimensional Fibrous Phosphorus Nanotubes.

The one-dimensional van der Waals (1D vdW) material fibrous red phosphorus (FRP) nanotubes are a promising direct-bandgap semiconductor with high carrier mobility and anisotropic optical responses because of low deformation potential and dangling-bond-free anisotropic interface. Employing first-principles calculations, we captured the potential of 1D FRP nanotubes. The thermal stability of 1D FRP nanotubes was confirmed by phonon calculation.

A Low-Concentration Electrolyte for High-Voltage Lithium-Metal Batteries: Fluorinated Solvation Shell and Low Salt Concentration Effect.

Concentration of electrolyte has significant effects on performances of rechargeable batteries. Previous studies mainly focused on concentrated electrolytes. So far, only several recipes on low-concentration electrolytes were studied, performing enhanced performance in advanced rechargeable batteries.

The mechanism of carbon source utilization by microalgae when co-cultivated with photosynthetic bacteria.

Microalgae-photosynthetic bacteria (PSB) co-culture, which is promising for wastewater treatment and lipid production, is lacking of study. In this work, the combinations of 3 microalgae and 3 PSB strains were firstly screened and then different inoculation ratios of the co-cultures were investigated. It was found the best promotion was Chlorella pyrenoidosa/Rhodobacter capsulatus co-culture (1:1), where the biomass productivity, acetate assimilation rate and lipid productivity were 1.

Fast response electrically controlled liquid crystal lens array for high resolution 2D/3D switchable display.

A fast response electrically controlled liquid crystal (LC) lens array is revealed. In order to realize the fast response, a double LC layer structure is adopted. The fabricated LC lens array has a small pitch of 310µm and LC layer with a thickness of 50μm.

Heat-Assisted Dual Neutral Spray Ionization for High-Performance Online Desalting in Mass Spectrometric Analysis.

In mass spectrometry (MS), nonvolatile salts contaminate the transmission system and cause ion suppression, hampering MS analysis. When MS is combined with liquid chromatography (LC) that uses a salty mobile phase, the problems become more intractable due to long analysis time. Here, a novel heat-assisted dual neutral spray ionization (HADSI) method was developed, which projected sample solution spray and solvent spray onto a heated plate to achieve online desalting and high ionization.

Clinical Performance of Rapid Antigen Tests for the Detection of SARS-CoV-2 Infection in the Emergency Department and Community: A Retrospective Study.

Background: Rapid antigen tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection have been authorized for emergency use (EUA); however, the performance has not been fully evaluated in clinical contexts. This study aimed to provide evidence regarding the diagnostic performance of SARS-CoV-2 rapid antigen tests compared with the real-time reverse transcription-polymerase chain reaction (RT-PCR) test in the emergency department (ED) and community.

Methods: Patients who underwent SARS-CoV-2 rapid antigen tests using the VTRUST COVID-19 Antigen Rapid Test (TD-4531) and real-time RT-PCR on the same day in the ED or community from May 24, 2021, to June 24, 2021, were examined.

Ac2‑26 alleviates hepatic ischemia‑reperfusion injury based on inhibiting the positive feedback loop of HMGB1/TLR4/NF‑κB/neutrophils.

Inflammation is one of the most crucial mechanism underlying hepatic ischemia-reperfusion injury (HIRI). Several studies have shown that Ac2-26, the active terminal peptide of Annexin A1, could modulate anti-inflammatory processes and protect the organs from ischemia-reperfusion injury (IRI). However the effects of Ac2-26 on an HIRI model have not been reported to date.