Correction: Neuroprotective effect of Kaempferol Glycosides against brain injury and Neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke.

[This corrects the article DOI: 10.1371/journal.pone.

Hydrogel membranes in organ-on-a-chip devices: A review.

Organ-on-a-chip (OoC) devices represent advanced in vitro models enabling to mimic the human tissue architecture function and physiology, providing a promising alternative to the traditional animal testing methods. These devices combine the microfluidics with soft materials, specifically hydrogel membranes (HMs) for mimicking the extracellular matrix (ECM) and biological barriers, such as the blood-brain barrier (BBB). Hydrogels are ideal biomaterials for OoC systems because of their tunable properties, biocompatibility, biodegradability, and microscale self-assembly.

Payoff Control in Multichannel Games: Influencing Opponent Learning Evolution.

In this article, we introduce a new theory for payoff control in multichannel learning environments, where agents interact with each other over multiple channels and each channel is a repeated normal form game. We propose two payoff control strategies-partial control and full control-that allow a single agent to set an upper bound to the opponent's expected payoffs summed across all channels, even if the opponent is a reinforcement learning agent. We prove that a partial (or full) control strategy can be obtained by solving a system of inequalities, and characterize the conditions under which such a partial (or full) control strategy exists.

Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study.

Transcriptome-wide association studies (TWASs) have the potential to identify susceptibility genes associated with testicular germ cell tumors (TGCTs). We conducted a comprehensive TGCT TWAS by integrating genome-wide association study (GWAS) summary data with predicted expression models from normal testis, TGCT tissues, and a cross-tissue panel that encompasses shared regulatory features across 22 normal tissues, including the testis. Gene associations were evaluated while accounting for variant-level effects from GWASs, followed by fine-mapping analyses in regions exhibiting multiple TWAS signals, and finally supplemented by colocalization analysis.

Study on Quality Markers of Tibetan Medicine Wuwei Shaji San Based on UHPLC-Q-Exactive Orbitrap-MS and Network Pharmacology Multicomponent Quantification.

The Tibetan medicine Wuwei Shaji powder (WWSJ) has been extensively applied to treating lung diseases such as chronic obstructive pulmonary disease (COPD). However, there are significant limitations in its quality control and evaluation. The purpose of this study was to analyze the overall chemical composition of WWSJ and to predict potential quality markers for WWSJ in the treatment of COPD.

Dynamic incentives and environmental feedback in public goods games: Promoting cooperation through critical thresholds.

Understanding the emergence and maintenance of cooperation in multiplayer games is a significant challenge across various theoretical disciplines. In this paper, we introduce an innovative model to study the impacts of environmental feedback in systems with critical thresholds. Different from prior studies on public goods games with environmental feedback, we propose that the system holds expectations for collective behavior, and the dynamic incentives are equal for all group members.

High-Performance TiCT-MXene/Mycelium Hybrid Membrane for Efficient Lead Remediation: Design and Mechanistic Insights.

This study presents a hybrid microfiltration technology designed for high-performance lead (Pb(II)) remediation, especially from aqueous solutions with high Pb(II) concentrations, by utilizing two-dimensional (2D) TiCT-MXene layers deposited on dry mycelium membranes. The hybrid TiCT-MXene/mycelium (MyMX) membranes were fabricated via a single-step electrochemical deposition (ECD) technique, which enabled a uniform coating of 2D TiCT-MXene onto individual hyphal fibers of a prefabricated mycelium membrane. Optimized ECD parameters for high Pb(II) uptake were identified using scanning electron microscopy and energy-dispersive X-ray spectroscopy.

Predicting TNFRSF4 expression and prognosis in head and neck squamous cell carcinoma tissue: a pathological image analysis approach.

Head and neck squamous cell carcinoma (HNSCC) exhibits a poor 5-year survival rate. TNFRSF4 is gaining attention in tumor therapy. The objective of this study was to forecast the expression of TNFRSF4 in HNSCC tissue using analysis of pathological images and investigate its possible molecular mechanisms.

Proteomic analysis of effects of 1% atropine in myopia therapy in Guinea pigs.

Myopia is a significant global public health issue. Key interventions for managing myopia include atropine treatment, optical correction, and surgical methods. This study focused on evaluating alterations in retinal protein expression after atropine therapy for myopia.

Factors Associated with Potentially Preventable Hospitalizations for COPD Patients: A Qualitative Analysis of Patient Perspectives.

Purpose: Ambulatory Care Sensitive Conditions (ACSCs) refer to hospital encounters that could potentially be prevented with improved primary care. Chronic Obstructive Pulmonary Disease (COPD) as one of the typical ACSCs, and its hospitalization is considered potentially preventable through the quality primary care. However, the literature on factors influencing Potentially Preventable Hospitalization (PPH) has rarely been conducted from the patient perspective, especially in China.

Primary angle-closed diseases recognition through artificial intelligence-based anterior segment-optical coherence tomography imaging.

Purpose: In this study, artificial intelligence (AI) was used to deeply learn the classification of the anterior segment-Optical Coherence Tomography (AS-OCT) images. This AI systems automatically analyzed the angular structure of the AS-OCT images and automatically classified anterior chamber angle. It would improve the efficiency of AS-OCT image analysis.

Mapping the Binding Hotspots and Transient Binding Pockets on V-Domain Immunoglobulin Suppressor of T Cell Activation Protein Surface.

V-domain immunoglobulin suppressor of T cell activation (VISTA), an inhibitory immune checkpoint present on both immune and tumor cells, has emerged as a highly promising target for cancer therapy due to its potential to overcome resistance encountered with existing immune checkpoint treatments. VSIG-3 is determined as an inhibitory ligand for VISTA, leading to the suppression of T cell proliferation. However, hotspots between VISTA/VSIG-3 protein-protein interaction remain ambiguous, mainly attributed to the lack of the structure of the VISTA/VSIG-3 complex.

Effects of Half-Time Re-Warm-Up With Core Strength Exercises on Subsequent Agility and Power Performance in Basketball Players.

Yang, Y-R, Chen, C, Pan, C-H, Yen, S-Y, and Cheng, C-F. Effects of half-time re-warm-up with core strength exercises on subsequent agility and power performance in basketball players. J Strength Cond Res 39(1): 62-69, 2025-This study investigated the effects of half-time re-warm-up (RW) comprising core strength exercise (CSE) on basketball players' subsequent power and change of direction (COD) performance.

Recent advances in the organocatalytic synthesis of chiral C3-spiro-cyclopentaneoxindoles.

Although there have been various reviews on the asymmetric construction of C3-spirooxindoles, there is a scarcity of reviews focusing on the asymmetric organocatalytic synthesis of C3-spiro-cyclopentaneoxindole derivatives. This particular scaffold has garnered significant attention from synthetic chemists due to its relevance in medicinal chemistry. In this review, we provide an overview of recent advancements in the asymmetric organocatalytic synthesis of various C3-spiro-cyclopentaneoxindoles using organic catalysts.

Costunolide and dehydrocostus lactone alleviate ulcerative colitis via regulating TLR4, NF-κB and PI3K expression.

In this study, we aimed to study the mechanism of costunolide (COS) and dehydrocostus lactone (DEH) in the treatment of ulcerative colitis (UC) based on network pharmacology, molecular docking and animal experiments. Firstly, network pharmacology was used to predict the target proteins of compounds and diseases. Subsequently, the network analysis was performed, and the key target proteins were screened out.

Virtual Screening and Biological Evaluation of Natural Products as Novel VPS34 Inhibitors that Modulate Autophagy.

VPS34 is a sole member of class III phosphoinositide 3-kinase involved in endosomal trafficking and autophagosome formation, making it an interesting target for cancer treatment. Here, we investigated 5,774 natural products using structure-based virtual screening against human VPS34. 10 natural products identified by virtual screening were purchased and tested in VPS34 ADP-Glo assay, yielding several potential VPS34 inhibitors.

Skill matters: Dynamic skill learning for multi-agent cooperative reinforcement learning.

With the popularization of intelligence, the necessity of cooperation between intelligent machines makes the research of collaborative multi-agent reinforcement learning (MARL) more extensive. Existing approaches typically address this challenge through task decomposition of the environment or role classification of agents. However, these studies may rely on the sharing of parameters between agents, resulting in the homogeneity of agent behavior, which is not effective for complex tasks.

Single-cell mapping of peripheral blood mononuclear cells reveals key transcriptomic changes favoring coronary artery lesion in IVIG-resistant Kawasaki disease.

Background: Intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) poses a considerable challenge to patients and their families due to its severe complications. Previous researches have highlighted the critical role of immune disorders in its pathogenesis. However, fragmented studies based on isolated cases hinder a comprehensive understanding of this deadly illness.

QBT improved cognitive dysfunction in rats with vascular dementia by regulating the Nrf2/xCT/GPX4 and NLRP3/Caspase-1/GSDMD pathways to inhibit ferroptosis and pyroptosis of neurons.

Background: The novel phthalein component QBT, extracted from Ligusticum chuanxiong, shows promising biological activity against cerebrovascular diseases. This study focused on ferroptosis and pyroptosis to explore the effects of QBT on nerve injury, cognitive dysfunction, and related mechanisms in a rat model of vascular dementia (VaD).

Methods: We established a rat model of VaD and administered QBT as a treatment.

Injectable dual drug-loaded thermosensitive liposome-hydrogel composite scaffold for vascularised and innervated bone regeneration.

Adequate blood supply and thorough innervation are essential to the survival of tissue-engineered bones. Though great progress has been created in the application of bone tissue engineering technology to bone defect repair, many challenges remain, such as insufficient vascularisation and deficient innervation in newly regenerated bone. In the present study, we addressed these challenges by manipulating the bone regeneration microenvironment in terms of vascularisation and innervation.

High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in .

The burgeoning emergence of drug-resistant strains poses a significant challenge to the clinical success of eradication therapies and is primarily attributed to mutations within drug-targeting genes that lead to antibiotic resistance. This study investigated the effect of high salt conditions on the occurrence of drug-resistance mutations in . We found that high salt condition significantly amplifies the frequency of drug resistance mutations in .

Continuous glucose monitoring versus conventional glucose monitoring in the ICU: A randomized controlled trial.

Purpose: This study evaluated the clinical utility of continuous glucose monitoring system (CGMS) in critically ill patients.

Methods: In this randomized controlled trial, we randomly assigned critically ill participants with diabetes or stress-induced hyperglycemia to the CGMS group (n = 48) or to the conventional point-of-care monitoring (POCM) group (n = 48). The glucose values and clinical outcome were compared between the two group.