Differences in clinical phenotype, laboratory, and imaging manifestations between AQP4 IgG positive and AQP4 MOG IgG double negative NMOSD: How to correctly diagnose the two.

Neuromyelitis optica spectrum disorders (NMOSD) is an uncommon autoimmune inflammatory demyelinating disorder of the central nervous system (CNS) and causes severe disability and even death. Aquaporin-4 immunoglobulin G (AQP4-IgG) antibody has been confirmed as the key pathogenic factor for development of NMOSD and leading to repeatting acute attacks. However, 20-40 % of NMOSD patients lack both AQP4-IgG and anti-myelin oligodendrocytes glycoproteins (MOG) IgG, in which the pathogenic factor is still unclear.

Cathelicidin-HG alleviates psoriasis by targeting glycoprotein VI to inhibit platelet-neutrophil complexes formation.

Psoriasis, a chronic inflammatory skin disorder, is characterized by a complex interplay among immune cells. Although the specific mechanisms of platelet involvement in psoriasis are not fully elucidated, platelet activation is considered a major pathogenic factor. In this study, we investigated the role of Cathelicidin-HG (Cath-HG), a peptide derived from Hylarana guentheri skin that exhibits potent inhibitory activity against platelet glycoprotein VI (GPVI), in an imiquimod-induced psoriasis mouse model.

Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3.

Metabolic enzymes play significant roles in the pathogenesis of various cancers through both canonical and noncanonical functions. Hexokinase domain-containing protein 1 (HKDC1) functions beyond glucose metabolism, but its underlying mechanisms in tumorigenesis are not fully understood. Here, we demonstrate that nuclear-localized HKDC1 acts as a protein kinase to promote hepatocellular carcinoma (HCC) cell proliferation.

Hypofractionated partial breast irradiation after breast-conserving surgery for patients with early stage breast cancer in China Mainland: a single-arm prospective trial.

To report the results of a single-arm, prospective partial breast irradiation (PBI) trial from China mainland using a dose of 40.05 Gy in 15 fractions delivered with intensity-modulated radiation therapy (IMRT) technique for patients with early stage breast cancer. Patients aged ≥ 50 years who underwent breast-conserving surgery for unifocal non-lobular invasive breast cancer, with pathological T1 disease, clear margins, negative axillary nodes, and positive hormonal receptors, were recruited.

The computerized algorithm for renal assessment improves diagnostic accuracy of renal impairment in hospitalized patients.

In hospitalized patients, acute kidney injury (AKI) is an important adverse event associated with high mortality and medical costs. Accurate diagnosis and timely management of AKI are essential for improving the outcomes of in-hospital AKI, and delayed diagnosis or misdiagnosis hinders advancements in AKI care. To ameliorate this problem, several electronic AKI alert systems have been proposed but have shown inconsistent effects on AKI outcomes.

TRIM21-mediated PRMT1 degradation attenuates colorectal cancer malignant progression.

Tripartite motif-containing 21 (TRIM21) plays a crucial role in antiviral responses and autoimmune diseases. While the impact of TRIM21 on cancer has been studied in various tumors, its role in colorectal cancer (CRC) remains unclear. In this study, we found that TRIM21 expression is reduced in primary CRC tissues.

Diurnal rhythm-modulated transcriptome analysis of meibomian gland in hyperlipidemic mice using RNA sequencing.

Aim: To explore the regulatory mechanism of meibomian gland (MG) in hyperlipidemic mice under a diurnal rhythm by transcriptomic analysis based on high-throughput sequencing.

Methods: The mouse model of hyperlipidemia induced by four months of high-fat diet (HFD) feeding to a regular light-dark (LD) cycle for 2 weeks was used in this study. Phenotypic observation and RNA sequencing (RNA-seq) of MGs of the experimental mice were then performed to investigate transcriptional changes due to hyperlipidemia and the diurnal rhythm and their effects on meibomian gland dysfunction (MGD).

Robustness of radiomics within photon-counting detector CT: impact of acquisition and reconstruction factors.

Objectives: To assess the impact of acquisition and reconstruction factors on the robustness of radiomics within photon-counting detector CT (PCD-CT).

Methods: A phantom with twenty-eight texture materials was scanned with different acquisition and reconstruction factors including reposition, scan mode (standard vs high-pitch), tube voltage (120 kVp vs 140 kVp), slice thickness (1.0 mm vs 0.

The associations between fresh vegetable and fruit consumption and plasma and PET biomarkers in preclinical Alzheimer's disease: A cross-sectional and longitudinal study of Chinese population.

Background: The identification of the modifiable lifestyle factors including dietary habits in older adults of preclinical Alzheimer's disease (AD) and early effective interventions are of great importance.

Objectives: We studied whether the consumption of fresh vegetables and fruits was different between cognitively unimpaired (CU) and cognitively impaired (CI) population and mainly investigated the associations between vegetable and fruit consumption and PET and plasma AD biomarkers in older CU adults with higher β-amyloid (Aβ) burden.

Design, Setting, And Participants: Older adults with the age of 50-85 years were enrolled for a cross-sectional and longitudinal study.

Bi-directional communication between intrinsic enteric neurons and ILC2s inhibits host defense against helminth infection.

Emerging studies reveal that neurotransmitters and neuropeptides play critical roles in regulating anti-helminth immune responses, hinting at the potential of intrinsic enteric neurons (iENs) in orchestrating intestinal immunity. Whether and how iENs are activated during infection and the potential neuroimmune interactions involved remain poorly defined. Here, we found that helminth infection activated a subset of iENs.

Lactate homeostasis is maintained through regulation of glycolysis and lipolysis.

Lactate is among the highest flux circulating metabolites. It is made by glycolysis and cleared by both tricarboxylic acid (TCA) cycle oxidation and gluconeogenesis. Severe lactate elevations are life-threatening, and modest elevations predict future diabetes.

Preferred Parental Language and Neurodevelopmental Outcomes Among Infants With Acute Provoked Neonatal Seizures in the United States.

Background: Parental non-English language preference (NELP) is associated with worse pediatric health outcomes. However, little is known about its relationship with developmental outcomes in infants with neonatal seizures. This study evaluated the relationship between parental NELP and neurodevelopment in a multicenter cohort of infants with neonatal seizures.

Potential prognostic and immunologic significances of ADAM8 in clear cell renal cell carcinoma.

Background: A Disintegrin And Metalloproteinase 8 (ADAM8) has been implicated in the development and progression of several cancers. However, further studies are needed to determine the value of ADAM8 in ccRCC. The research aimed to investigate the prognostic and immunologic significance of ADAM8 in ccRCC from the perspective of bioinformatics.

Photonic crystal fiber based on graphene surface plasmon resonance for high-sensitivity terahertz refractive index sensing.

A photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) with a graphene coating on the cladding is designed for refractive index (RI) detection in the range of 0.3-0.5 THz, especially for liquid bioanalytical sensing.

Internally focused phase optical transfer function for spatial light interference microscopy.

The phase optical transfer function (POTF) is a critical aspect of image formation theory for high-resolution phase imaging such as spatial light interference microscopy. However, current analytic formulae for the POTF do not match experimental results. Further, when used for deconvolution, halo artifacts still persist, and the contrast improvement is rather limited.

Simulation analysis of a photonic crystal fiber refractive index sensor based on a double-layer film structure and surface plasmon resonance technology.

A photonic crystal fiber surface plasmon resonance sensor based on a double-layer membrane structure is designed and analyzed. In the simple sensing structure with only one air hole size, and Au layers with specific thicknesses are sequentially coated on the optical fiber to form a double-layer structure. The sensing characteristics of the double-layer membrane structure are studied by the finite element method.

Double-formant PCF-SPR refractive index sensor with ultra-high double-peak-shift sensitivity and a wide detection range.

A dual-resonance-peak photonic crystal fiber-surface plasmon resonance (PCF-SPR) refractive index (RI) sensor is designed for different wavelength ranges. The first resonance peak of the sensor is distributed in the wavelength range of 700-2350 nm, while the second peak is distributed in the range of 2350-5550 nm. In addition to detecting analytes using the full spectrum of constraint losses (CLs), it is also possible to use a single resonance peak to achieve the detection of analytes.

Post-removal for the deposited Au metal to increase the light extraction efficiency for AlGaN-based deep-ultraviolet light-emitting diodes.

Ni/Au is employed to ensure a high-quality p-type ohmic contact for most AlGaN-based deep-ultraviolet light-emitting diodes (DUV LEDs). However, the substantial absorptivity of ultraviolet light by Ni/Au significantly impacts the light extraction efficiency (LEE). In this work, to reduce the absorptivity of a Ni/Au electrode, we conduct wet-etching to the Ni/Au electrode after the formation of ohmic contact between Ni/Au and p-AlGaN.

Alterations in Protein Phosphorylation and Arginine Biosynthesis Metabolism Confer β-Phenylethanol Tolerance in Saccharomyces cerevisiae.

The aromatic compound β-phenylethanol (2-PE) is inherently toxic and can inhibit cell activity in Saccharomyces cerevisiae, making it highly challenging to enhance strain tolerance through rational design due to the lack of reliable connections between tolerance phenotype and genetic loci. This study employed adaptive laboratory evolution strategy to investigate the tolerance characteristics of S. cerevisiae S288C under inhibitory concentrations of 2-PE.

3D Printed Spectroelectrochemical Platform for Redox-Based Bioelectronics.

Redox provides unique opportunities for interconverting molecular/biological information into electronic signals. Here, the fabrication of a 3D-printed multiwell device that can be interfaced into existing laboratory instruments (e.g.

A Transformative Wearable Corneal Microneedle Patch for Efficient Therapy of Ocular Injury and Infection.

Ocular injury and infection are significant causes of vision impairment and blindness globally. Effective treatment is, however, challenging due to the physical barrier of the cornea, which restricts drug penetration in the eye, as well as the presence of eye injury that necessitates continuous delivery of growth factors on the ocular surface for cornea healing. Here, we introduce a transformative wearable corneal microneedle (MN) patch designed for efficient therapy of ocular injury and infection.

Exploration of Multidimensional Structural Optimization and Regulation Mechanisms: Catalysts and Reaction Environments in Electrochemical Ammonia Synthesis.

Ammonia (NH) is esteemed for its attributes as a carbon-neutral fuel and hydrogen storage material, due to its high energy density, abundant hydrogen content, and notably higher liquefaction temperature in comparison to hydrogen gas. The primary method for the synthetic generation of NH is the Haber-Bosch process, involving rigorous conditions and resulting in significant global energy consumption and carbon dioxide emissions. To tackle energy and environmental challenges, the exploration of innovative green and sustainable technologies for NH synthesis is imperative.

Mesenchymal Stem Cells With Polydopamine-Coated NaGdF Nanoparticles with Ca Chelation Ability for Ischemic Stroke Therapy.

Mesenchymal stem cells (MSCs) transplantation is a promising therapeutic strategy for ischemic stroke. However, the survival of transplanted MSCs is often compromised by the excessive levels of reactive oxygen species (ROS) and calcium ions (Ca) in the ischemic microenvironment following blood flow occlusion. In this study, a protective strategy is developed using functional nanomaterials to escort and shield MSCs.

Simultaneous whole-brain and cervical spine imaging at 7 T using a neurovascular head and neck coil with 8-channel transceiver array and 56-channel receiver array.

Purpose: To develop a 7T neurovascular head and neck (NVHN) coil with an extended longitudinal coverage of the brain and cervical spine, with eight transceiver (TxRx) channels and 56 receive (Rx) channels for dynamic parallel-transmit (pTx) applications.

Methods: A dual-row transceiver array with six elements in the upper row and two elements in the lower row was designed using combined electromagnetic and circuit optimization and constructed. A 56Rx array covering the brain and cervical spine was designed and combined with the transceiver array.

Dectin-1 stimulating β-glucans inhibit Chlamydia infections both in vitro and in vivo.

Chlamydia trachomatis and Candida albicans are common inhabitants of the female genital tract. Candida albicans can impact the viability and pathogenesis of some bacteria. Previously, we investigated physical interactions between Ch.