Publications by authors named "Chrystalla Constantinou"
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single-nucleus RNA sequencing, we characterized the transcriptome of 880,000 nuclei from 18 control and 61 failing, nonischemic human hearts with pathogenic variants in DCM and ACM genes or idiopathic disease. We performed genotype-stratified analyses of the ventricular cell lineages and transcriptional states.
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- * Researchers investigated how paracrine signals from cardiac mesenchymal stromal cells (cMSCs) impacted human heart cells, finding that these signals significantly reduced cell death in human cardiomyocytes compared to other cell types.
- * The study suggests that the secreted factors from cMSCs, which protect heart cells by preventing apoptosis and maintaining cell function, could lead to new, effective cell-free therapies for heart conditions.
Satellite cells are responsible for skeletal muscle regeneration. Upon activation, they proliferate as transient amplifying myoblasts, most of which fuse into regenerating myofibers. Despite their remarkable differentiation potential, these cells have limited migration capacity, which curtails clinical use for widespread forms of muscular dystrophy.
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