Publications by authors named "Christy Zheng"
Article Synopsis
- Estrogen receptor-positive (ER-positive) breast cancer often recurs later after initial treatment, and high levels of the protein GRHL2 are linked to a worse prognosis compared to ER-negative types.
- *GRHL2 boosts traits associated with stem cells and dormancy in ER-positive breast cancer cells, resulting in a stronger epithelial identity and a shift towards a hybrid epithelial to mesenchymal transition (EMT).
- *Research shows that increased GRHL2 leads to reduced cell growth and greater dormancy marker expression, along with enhanced self-renewal capabilities and changes in influential transcription factor motifs, suggesting it plays a significant role in cancer progression.*
Synthetic biodegradable polyesters for implantable controlled-release devices.
Expert Opin Drug Deliv
October 2022
Introduction: Implantable devices can be designed to release drugs to localized regions of tissue at sustained and reliable rates. Advances in polymer engineering have led to the design and development of drug-loaded implants with predictable, desirable release profiles. Biodegradable polyesters exhibit chemical, physical, and biological properties suitable for developing implants for pain management, cancer therapy, contraception, antiviral therapy, and other applications.
View Article and Find Full Text PDFPhosphorylation of estrogen receptor α (ER) at serine 118 (pS118-ER) is induced by estrogen and is the most abundant posttranslational mark associated with a transcriptionally active receptor. Cistromic analysis of pS118-ER from our group revealed enrichment of the GRHL2 motif near pS118-ER binding sites. In this study, we used cistromic and transcriptomic analyses to interrogate the relationship between GRHL2 and pS118-ER.
View Article and Find Full Text PDFArticle Synopsis
- Implanted materials in the body trigger a reaction called the foreign body reaction (FBR), which involves different immune cells that help heal and surround the materials.
- Special immune cells called macrophages are very important in the early stages of this reaction and can form larger cells known as foreign body giant cells.
- Some research shows that other immune cells, like T and B cells, might also play a role in the FBR, but scientists are still figuring out how important they are and how they communicate with each other during this process.