Tridentate NacNac Tames T-Shaped Nickel(I) Radical.

The reaction of a nickel(II) chloride complex containing a tridentate β-diketiminato ligand with a picolyl group [2,6-iPr -C H NC(Me)CHC(Me)NH(CH py)]Ni(II)Cl (1)] with KSi(SiMe ) conveniently afforded a nickel(I) radical with a T-shaped geometry (2). The compound's metalloradical nature was confirmed through electron paramagnetic resonance (EPR) studies and its reaction with TEMPO, resulting in the formation of a highly unusual three-membered nickeloxaziridine complex (3). When reacted with disulfide and diselenide, the S-S and Se-Se bonds were cleaved, and a coupled product was formed through carbon atom of the pyridine-imine group.

Tridentate NacNac Stabilized Tin and Nickel Complexes: Access to a Monomeric Nickel Hydride and Its Catalytic Application.

The transmetalation reaction of picolyl-supported tridentate nacnac germylene monochloride [2,6-Pr-CHNC(Me)CHC(Me)NH(CHpy)]GeCl () (py = pyridine) with SnCl results in an analogous stannylene chloride (). The three-coordinated stannylenium cation [{2,6-Pr-CHNC(Me)CHC(Me)NH(CHpy)}Sn] with SnCl as a counteranion () has been generated through the abstraction of chloride ligand from using an additional equivalent of SnCl. Instead of forming a donor-acceptor complex, undergoes a facile redox transmetalation reaction with Ni(COD) (COD = cyclooctadiene) and CuCl to afford analogous nickel and copper complexes [2,6-Pr-CHNC(Me)CHC(Me)NH(CHpy)]MCl [M = Ni () and Cu ()].

Crystal structure of a 1:1 co-crystal of the anti-cancer drug gefitinib with azelaic acid.

In the title co-crystal, CHClFNO·CHO, gefitinib (GTB; systematic name: quinazolin-4-amine) co-crystallizes with azelaic acid (AA; systematic name: nona-nedioic acid). The co-crystal has the monoclinic 2/ centrosymmetric space group, containing one mol-ecule each of GTB and AA in the asymmetric unit. A structure overlay of the GTB mol-ecule in the co-crystal with that of its most stable polymorph revealed a significant difference in the conformation of the morpholine moiety.