Publications by authors named "Christy L Dyer"
Bioorg Med Chem
August 2022
Article Synopsis
- Large conductance, calcium/voltage-gated potassium channels (BK) play a vital role in various body functions and are particularly important in smooth muscle (SM) due to the high expression of accessory beta1 subunits.
- Pharmaceutical development targeting beta1 may help treat smooth muscle disorders like hypertension, but previous compounds have shown low effectiveness and unwanted side effects.
- Research identified a potent activator and a potent antagonist for beta1-dependent BK, providing initial evidence that both types of compounds can effectively modulate BK activity in a targeted manner.
