Publications by authors named "Christy D B Gray"
Molecular Mechanisms of Anesthetic Neurotoxicity: A Review of the Current Literature.
J Neurosurg Anesthesiol
October 2016
Article Synopsis
- Exposure to anesthetic agents during early postnatal life may lead to long-term cognitive impairments due to disruptions in brain development, though the exact mechanism is still unknown.
- Current research, mainly involving rodent models, investigates various potential molecular mechanisms of anesthetic toxicity, including effects on cell death, growth factor signaling, neurotransmitter receptors, mitochondria, and epigenetic modifications.
- Despite exploring several promising research avenues, there is currently no agreement on a definitive cause of injury related to anesthetic exposure in developing brains.