Publications by authors named "Christos S Georgiades"

Purpose: To determine whether celiac ganglion block can serve as a diagnostic test for dysautonomia as the cause of gastrointestinal dysmotility-related symptoms.

Materials And Methods: This was an institutional review board-approved, prospective, single-arm, registered study, from January 2020 to May 2021, and included patients aged 14-85 years with gastrointestinal symptoms of food intolerance, abdominal pain, or angina. Patients with nonneurogenic causes (ie, chronic cholecystitis, peptic ulcer disease, gastroesophageal reflux, and malabsorption syndrome) were excluded.

View Article and Find Full Text PDF

Spontaneous breast hematoma is a rare complication of therapeutic anticoagulation therapy with few cases reported in the literature. We present a case of spontaneous breast hematoma resulting in hypotension and symptomatic anemia. Angiography demonstrated multiple sites of hemorrhage within the breast, which was treated with gelatin sponge embolization.

View Article and Find Full Text PDF

Background Percutaneous cryoablation (PCA) is an increasingly utilized treatment for stage I renal cell carcinoma (RCC), albeit without supportive level I evidence. Purpose Primary objective was to determine the 10-year oncologic outcomes of PCA for stage I RCC in a prospective manner. Secondary objectives were to compare outcomes after partial nephrectomy (PN) and radical nephrectomy (RN) from the National Cancer Database (NCDB), to determine long-term renal function, and to determine the risk of metachronous disease.

View Article and Find Full Text PDF

Context And Objective: Bilateral adrenal vein sampling (AVS), the diagnostic standard for identifying surgically remediable aldosteronism (SRA), is commonly performed after cosyntropin stimulation (post-ACTHstim). The role of AVS without cosyntropin stimulation (pre-ACTHstim) has not been established. The selectivity index (SI), the adrenal vein (av) serum cortisol concentration divided by that in a peripheral vein, confirms av sampling.

View Article and Find Full Text PDF

Introduction: The objective was to determine the ablation size of a single 15-min freeze and compare it with the conventional 10-min freeze-8-min thaw-10-min freeze protocol. Secondary objectives were to determine the ablation margin and to ascertain whether islands of viable tissue remain within the ablation zone.

Materials And Methods: Five adult swine under general anesthesia were used.

View Article and Find Full Text PDF

Purpose: Primary hyperhidrosis (PH) typically involves the craniofacial (CF) or axillary-palmar (AP) region. Our purpose was to determine the safety and efficacy of CT-guided sympatholysis for treating PH.

Methods: In this prospective study, 39 consecutive patients with CF or AP PH were referred for percutaneous sympatholysis.

View Article and Find Full Text PDF

Compensatory hyperhidrosis (CH) is common after sympathectomy, and most treatments are ineffective. We present a 36-year-old man whose CH was effectively treated with percutaneous sympatholysis. The patient's axillary-palmar hyperhidrosis had been treated with T3-4 sympathetic ligation.

View Article and Find Full Text PDF

The number of new cases of renal cell carcinoma has been steadily increasing since the 1960s, reaching 62,000 and 89,000 annually in the United States and Europe, respectively, in 2016. The current standard of care for early-stage disease is nephron-sparing surgery, which has a demonstrated long-term disease-free survival and an acceptable safety profile. Technical developments (thin, powerful probes and real-time image guidance systems) have allowed image-guided percutaneous ablation to become a viable option for stage I renal cell carcinoma.

View Article and Find Full Text PDF

Purpose: Cryoablation of renal tumors is assumed to have a higher risk of hemorrhagic complications compared to other ablative modalities. Our purpose was to establish the exact risk and to identify hemorrhagic risk factors.

Materials And Methods: This IRB approved, 7-year prospective study included 261 renal cryoablations.

View Article and Find Full Text PDF

Various chronic hematologic disorders that lead to ineffective hemopoiesis or inadequate bone marrow function (ie, chronic hemolytic anemias, thalassemia, sickle cell anemia, myelofibrosis of many causes, lymphoma, and leukemia) can potentially precipitate extramarrow new blood element creation. Extramarrow soft tissue that produces blood elements is called extramedullary hemopoietic tissue and the process extramedullary hemopoiesis (EMH). Sites commonly involved by EMH include the liver, spleen, lymph nodes, and most commonly, paravertebral regions, although other sites can sometimes be involved.

View Article and Find Full Text PDF

Amyloidosis is a collection of pathophysiologically related disease entities caused by the extracellular deposition of abnormal fibrillar proteins called amyloid. The accumulation of amyloid may be systemic, involving many organs, or localized manifesting as infiltration of individual organs, or in the form of a focal, tumorlike lesion. Amyloidosis may develop in the setting of underlying conditions, usually chronic inflammatory diseases, in which case it is termed secondary, or it may involve no underlying disease and thus be primary or idiopathic.

View Article and Find Full Text PDF

Purpose: Percutaneous cryoablation is gaining in popularity as a viable treatment option for renal cell carcinoma (RCC). We present the 5-year oncologic outcomes of a prospective trial.

Methods: Over a 5-year period, we treated 134 consecutive patients with biopsy-proven RCC with CT-guided percutaneous cryoablation.

View Article and Find Full Text PDF
Article Synopsis
  • - The study compared the effectiveness of surgical cryoablation (SCA) and percutaneous cryoablation (PCA) for treating renal tumors by analyzing the outcomes of 194 patients over a follow-up period.
  • - Both treatment methods yielded similar rates of overall survival (OS), cancer-specific survival (CSS), and recurrence-free survival (RFS), with five-year rates showing slight variations but no significant differences between the two approaches.
  • - PCA resulted in a much shorter hospital stay (0.7 days) compared to SCA (3.2 days), indicating it may be a more convenient option for patients while still offering effective treatment.
View Article and Find Full Text PDF

Purpose: Preservation of renal function is of paramount importance in patients with tumors in solitary kidneys. We compared the renal function and oncologic outcomes of patients treated by partial nephrectomy with those of patients treated by cryoablation for solitary kidney tumors.

Materials And Methods: All patients with solitary kidneys who were treated for renal tumors at our institution between 1997 and 2007 were included in the screen.

View Article and Find Full Text PDF

Introduction: The drop-off risk for patients awaiting liver transplantation for hepatocellular carcinoma (HCC) is 22%. Transplant liver availability is expected to worsen, resulting in longer waiting times and increased drop-off rates. Our aim was to determine whether chemoembolization can decrease this risk.

View Article and Find Full Text PDF

Purpose: We describe perioperative complications associated with renal cryoablation and identify potential risk factors for certain complications.

Materials And Methods: We retrospectively analyzed the medical records of patients with unifocal renal masses treated with cryosurgery at a single center between 1997 and 2007. All complications associated with these procedures were documented and classified into grades 1 to 5 by the Clavien surgical complication classification.

View Article and Find Full Text PDF
Article Synopsis
  • The study compares transarterial chemoembolization (CE) and yttrium-90 (90Y) radioembolization (RE) as treatment options for patients with liver-dominant metastatic colorectal cancer.
  • A total of 36 patients participated: 21 received CE and 15 received RE, with similar demographics and disease characteristics between the two groups.
  • Survival rates and complications were comparable, with median survival times of 7.7 months for CE and 6.9 months for RE, indicating both methods offer similar palliative benefits for patients.
View Article and Find Full Text PDF

Purpose: To determine the toxicity profile of transarterial chemoembolization (TACE) at 6 months and 1 year after treatment in patients with hepatocellular carcinoma (HCC) in a standardized oncology protocol so that TACE could be compared with systemic chemotherapeutic regimens for liver cancer.

Materials And Methods: The study was authorized by the institutional review board. Between January 2002 and January 2007, 190 patients (155 men, 35 women; median age, 65 years; age range, 18-84 years) with HCC who underwent TACE treatment were identified from a prospectively collected database.

View Article and Find Full Text PDF

Purpose: Image-guided percutaneous cryoablation is a treatment alternative for selected patients with renal cell carcinoma (RCC). The objective of the present study was to present the safety and efficacy of percutaneous cryoablation.

Materials And Methods: The study included 51 lesions in 46 consecutive patients treated with computed tomography (CT)-guided percutaneous cryoablation.

View Article and Find Full Text PDF

Objective: The purpose of this study was to assess the utility of assessment of tumor size and enhancement with diffusion-weighted and conventional MRI in the evaluation of response to transarterial chemoembolization therapy for metastatic ocular melanoma.

Conclusion: In patients with ocular melanoma and liver metastasis treated with transarterial chemoembolization, functional MRI showed significant changes in the lesions. These changes included a decrease in tumor enhancement and an increase in the apparent diffusion coefficient of the tumor, suggesting increasing tumor necrosis and cell death.

View Article and Find Full Text PDF

Purpose: To assess the value of functional magnetic resonance (MR) imaging in the evaluation of early tumor response after transarterial chemoembolization (TACE) for metastatic leiomyosarcoma and compare tumor response using functional MR imaging versus traditional imaging response assessment, which is based on tumor size.

Materials And Methods: We evaluated 31 lesions in 10 patients with liver metastases from leiomyosarcoma using MR imaging studies before and after TACE. Diffusion and contrast-enhanced MR imaging was performed on a 1.

View Article and Find Full Text PDF