Q Fever Severe Pericarditis With Cardiac Tamponade: A Case Report.

Q fever can present in acute or chronic form with a wide range of clinical symptoms and presentations. Here we report severe pericarditis with cardiac tamponade due to a chronic Coxiella burnetii (C. burnetii) infection.

Synthesis, Characterization, and X-ray Crystallography, of the First Cyclohexadienyl Trifluoromethyl Metal Complex (η-CH)Fe(CO)CF.

Fluorochemistry is a field of tremendous developments and advances in several areas of science including materials, pharmaceuticals and agriculture. This makes the design and synthesis of fluorine-containing substances highly desirable research targets. The sub-area of synthetic perfluorinated chemistry proportionately attracts widespread interest by applying to all areas of chemistry including organic and inorganic.

Syntheses and Characterization of the First Cycloheptatrienyl Transition-Metal Complexes with a M-CF Bond.

The organometallic chemistry of metal complexes with organocyclic ligands of higher than five hapticity is much more lacking than the chemistry of metal complexes with η-cyclopentadienyl ligands, which has been explored in considerable depth, resulting in novel advances. The main reason for this is stability. In particular, reports indicate that (η-CH)ML complexes are considerably less stable than analogous (η-CH)ML.

Myocardial fibrosis after COVID-19 infection and severe sinus arrest episodes in an asymptomatic patient with mild sleep apnea syndrome: A case report and review of the literature.

COVID-19 infection is a new disease mainly affecting the respiratory system but is also accompanied by many extra-pulmonary manifestations. A case of a 47-year old male with unique myocardial fibrosis after COVID-19 infection involving the left ventricular wall, intraventricular septum and almost complete damage of interatrial septum, in combination with asymptomatic severe sinus arrest episodes related to mild obstructive sleep apnea syndrome is described here.

Significant reduction in the visits to the emergency room department during the COVID-19 pandemic in a tertiary hospital in Greece: Indirect victims of the pandemic?

COVID-19 pandemic caused a major crisis, affecting and straining health care systems, including some very advanced ones. The pandemic may have also indirectly affected access to health care for patients with other conditions, not related to COVID-19, even in countries not overwhelmed by an outbreak.We analyzed and compared visits to the emergency room (ER) department during the same calendar period of 2019 and 2020 (from March 1 to March 31 of each year) in our hospital, a medium size, tertiary center, located in the center of Athens, which is not a referral center for COVID-19.

Effects of Mediterranean diet on hospital length of stay, medical expenses, and mortality in elderly, hospitalized patients: A 2-year observational study.

Objectives: The Mediterranean diet (MedDiet) has been related to reduced overall mortality and improved disease outcome. The aim of this study was to estimate the effects of the MedDiet on hospital length of stay (LOS), financial cost, and mortality (from hospitalization up to 24 mo afterward) in hospitalized patients >65 y of age.

Methods: Participating in this observational study were 183 patients >65 y of age, who were urgently admitted for any cause to the Internal Medicine Department of Argolidos General Hospital.

4f-Metal Clusters Exhibiting Slow Relaxation of Magnetization: A {Dy} Complex with An Hourglass-like Metal Topology.

The reaction between Dy(NO)∙6HO and the bulky Schiff base ligand, -naphthalidene-2-amino-5-chlorobenzoic acid (nacbH), in the presence of the organic base NEt has led to crystallization and structural, spectroscopic and magnetic characterization of a new heptanuclear [Dy(OH)(OMe)(NO)(nacb)(nacbH)(MeOH)(HO)](NO) () compound in ~40% yield. Complex has a unique hourglass-like metal topology, among all previously reported {Dy} clusters, comprising two distorted {Dy(μ-OH)(μ-OMe)} cubanes that share a common metal vertex (Dy2). Peripheral ligation about the metal core is provided by the carboxylate groups of four η:η:η:μ single-deprotonated nacbH and two η:η:η:η:μ fully-deprotonated nacb ligands.

'Metal Complexes as Ligands' for the Synthesis of Coordination Polymers: A Mn Monomer as a Building Block for the Preparation of an Unprecedented 1-D {MnMn} Linear Chain.

A relatively unexplored synthetic route in redox-active Mn(II/III) coordination chemistry has been employed toward the preparation of a new mixed-valence Mn 1-D linear chain from the reaction of [Mn(sacb)] precursor with a Mn source, where sacbH is the Schiff base ligand -salicylidene-2-amino-5-chlorobenzoic acid. The mononuclear (PrNH)[Mn(sacb)] () compound was obtained in excellent yields (>85%) from the 1:2:3 reaction of Mn(OCMe)∙4HO, sacbH and PrNH, respectively. In , the two doubly deprotonated sacb ligands act as O,N,O-tridentate chelates, while the second carboxylate O atom of sacb is dangling and H-bonded to the PrNH countercation.

Acute Heart Failure in a Healthy Young Patient after Severe Carbon Monoxide Poisoning.

Introduction: Carbon monoxide (CO) poisoning may cause severe cellular hypoxia.

Materials And Methods: A 28-year-old male presented reduced levels of consciousness and dyspnoea after CO exposure. Clinical examination revealed tachypnoea, bilateral rales, dilated jugular veins and confusion.

Prognostic value of exercise tolerance test for predicting cardiovascular disease in asymptomatic individuals with heterozygous familiar hypercholesterolemia.

Heterozygous familiar hypercholesterolemia (hFH) is an autosomal dominant inherited dyslipidemia, associated with premature cardiovascular disease (CVD). Aim of the study was to define prognostic factors for cardiovascular events (CVE) in asymptomatic individuals with hFH. All participants with recent diagnosis of hFH were recruited from the outpatient lipid clinic from 1987 to 2016, without any previous clinical evidence of CVD.

Weil's disease with haemoptysis and acute respiratory distress syndrome.

A 35-year-old male patient reached the emergency department after an episode of massive haemoptysis a few hours ago. Fever and dyspnea were mentioned to be present the last 5 days. His medical history included only malaria, successfully treated 2 years ago.

The surprising pairing of 2-aminoimidazo[1,2-a][1,3,5]triazin-4-one, a component of an expanded DNA alphabet.

Synthetic biologists demonstrate their command over natural biology by reproducing the behaviors of natural living systems on synthetic biomolecular platforms. For nucleic acids, this is being done stepwise, first by adding replicable nucleotides to DNA, and then removing its standard nucleotides. This challenge has been met in vitro with `six-letter' DNA and RNA, where the Watson-Crick pairing `concept' is recruited to increase the number of independently replicable nucleotides from four to six.

Oximato-Based Ligands in 3 d/4 f-Metal Cluster Chemistry: A Family of {CuLn} Complexes with a "Propeller"-like Topology and Single-Molecule Magnetic Behavior.

The organic chelating and bridging ligands 9,10-phenanthrenedione-9-oxime (phenoxH) and 9,10-phenanthrenedione-9,10-dioxime (phendoxH) were synthesized and subsequently employed for the first time in heterometallic 3 d/4 f-metal cluster chemistry. The general reaction between CuCl·2HO, LnCl·6HO, phenoxH, and NEt in a 1:2:2:4 molar ratio, in a solvent mixture comprising MeCN and MeOH, afforded brown crystals of a new family of [CuLnCl(phenox)(MeOH)] clusters (Ln = Gd (1), Tb (2), Dy (3)) that possess an unprecedented [CuLn(μ-NO)] "propeller"-like core. Complexes 1-3 are the first {CuLn} clusters in which the outer Cu and the central Ln atoms are solely bridged by diatomic oximato bridges.

Structural and Magnetic Variations in a Family of Isoskeletal, Oximate-Bridged {Mn M } Complexes (M =Mn, Gd, Dy).

The self-assembly reaction of MnCl ⋅4H O, acenaphthenequinone dioxime (acndH ) and NEt has yielded an unprecedented, linear {Mn Mn } complex with an S=5 spin ground state and non-SMM behavior. The targeted replacement of the central Mn ion with Gd and Dy ions has successfully increased the S and turned on the SMM dynamics without affecting the core structure and the nature of the magnetic exchange interactions.

Controlled Dimerization of Mn Single-Molecule Magnets.

Controlled dimerization of Mn single-molecule magnets (SMMs) was achieved via a synthetic route involving a competition between bridging and terminal ligands, namely, diols and alcohols. The reaction using a 1:1 ratio of the competing ligands resulted in the isolation of a new family of covalently linked dimers of Mn SMMs. This is the first step toward the controlled growth of SMM oligomeric arrays.

Treat-to-target biologic therapy in patients with rheumatoid arthritis is more efficacious and safe compared to delayed initiation of biologics: a real-world study.

Objectives: Rheumatoid arthritis (RA) is a chronic, devastating disease. Treat-to-target strategy (T2T) more than the usual care, reduces disease activity by using aggressively all therapeutic options. The aim of the study was to evaluate our hypothesis that T2T strategy using biologic disease-modifying anti-rheumatic drugs (bDMARDs), when needed, is also safer than the usual care characterised by delayed initiation of bDMARDs.

Introducing Dimensionality to the Archetypical Mn12 Single-Molecule Magnet: a Family of [Mn12]n Chains.

The [Mn12O12(O2CR)16(L4)] family (R = various; L = terminal ligand) of clusters holds a special place in molecular magnetism; they are the most well-studied single-molecule magnets (SMMs). Targeted linkage of these SMMs has now been achieved for the first time. The resulting chain structures have been confirmed crystallographically, and the magnetic properties, up to 1.

"Ligands-with-Benefits": Naphthalene-Substituted Schiff Bases Yielding New Ni(II) Metal Clusters with Ferromagnetic and Emissive Properties and Undergoing Exciting Transformations.

The initial employment of the fluorescent bridging ligand N-naphthalidene-2-amino-5-chlorobenzoic acid (nacbH2) in metal cluster chemistry has led to new Ni12 (1) and Ni5 (2) clusters with wheel-like and molecular-chain topologies, respectively. The doubly-deprotonated nacb(2-) ligands were found to adopt four different coordination modes within 1 and 2. The nature of the ligand has also allowed unexpected organic transformations to occur and ferromagnetic and emission behaviors to emerge.

Adverse events and infections in patients with rheumatoid arthritis treated with conventional drugs or biologic agents: a real world study.

Objectives: Treatment of rheumatoid arthritis (RA) with disease-modifying anti-rheumatic drugs (DMARDs), either synthetic (sDMARDs) or biologic agents (bDMARDs) has significantly improved disease outcome. However, the impact of therapy-related adverse events (AEs), mild, moderate or serious, on disease outcome is under debate. The purpose of the study was to test the hypothesis that AEs, including infections, are rather common in patients receiving bDMARDs than in those receiving sDMARDs.

Manganese/cerium clusters spanning a range of oxidation levels and CeMn(8), Ce(2)Mn(4), and Ce(6)Mn(4) nuclearities: structural, magnetic, and EPR properties.

The syntheses, structures, and magnetic properties are reported for three new Ce/Mn clusters with different Ce/Mn ratios: [Ce6Mn4O12(O2CMe)10(NO3)4(py)4] (py = pyridine) (1), [CeMn8O8(O2CCH2(t)Bu)12(DMF)14] (DMF = dimethylformamide) (2), and [Ce2Mn4O2(O2CMe)6(NO3)4(hmp)4] (3; hmp(-) is the anion of 2-(hydroxymethyl)pyridine). 1 and 2 were obtained from the reaction of Ce(IV) with [Mn12O12(O2CMe)16(H2O)4] (Mn(III)8Mn(IV)4) and [Mn8O2(O2CCH2(t)Bu)14((t)BuCH2CO2H)4] (Mn(II)6Mn(III)2), respectively, whereas 3 resulted from the oxidation of Mn(II) acetate with Ce(IV) in the presence of hmpH. Cluster 1 possesses an unusual [Ce6Mn4O12](14+) core topology consisting of a [Ce6O8] face-capped octahedron, which is face-fused at each end to a [Ce(IV)2Mn(III)Mn(IV)O4] cubane.

A MnII6MnIII6 single-strand molecular wheel with a reuleaux triangular topology: synthesis, structure, magnetism, and DFT studies.

The use of the anion of 3-methyl-1,3,5-pentanetriol (mpt(3-)) in manganese carboxylate chemistry has afforded the new Mn(II/III)12 cluster [Mn(II)6Mn(III)6(mpt)6(CH3CO2)12(py)6]·3CH3CN (1·3CH3CN). Complex 1 was isolated in moderate yield by the reaction of Mn(CH3CO2)2·4H2O and H3mpt in a 2.6:1 molar ratio in a solvent mixture of acetonitrile and pyridine.

Multiple, large granulomas in a patient with extensive intestinal tuberculosis.

A 42-year-old patient presented with low-grade fever, pain of the right iliac fossa, constipation and tendency to vomit. Clinical examination revealed abdominal wall rigidity and rebound tenderness of the right iliac fossa. The patient was operated immediately because of an acute abdomen and the probable diagnosis of ruptured appendicitis.

Synthesis, structure, and spectroscopic and magnetic characterization of [Mn12O12(O2CCH2But)16(MeOH)4]·MeOH, a Mn12 single-molecule magnet with true axial symmetry.

The synthesis and properties are reported of a rare example of a Mn(12) single-molecule magnet (SMM) in truly axial symmetry (tetragonal, I4). [Mn(12)O(12)(O(2)CCH(2)Bu(t))(16)(MeOH)(4)]·MeOH (3·MeOH) was synthesized by carboxylate substitution on [Mn(12)O(12)(O(2)CMe)(16)(H(2)O)(4)]·2MeCO(2)H·4H(2)O (1). The complex was found to possess an S = 10 ground state, as is typical for the Mn(12) family, and displayed both frequency-dependent out-of-phase AC susceptibility signals and hysteresis loops in single-crystal magnetization vs DC field sweeps.

Cervical epidural abscess caused by brucellosis.

A 70-year-old Greek lady presented with fever, arthralgias of knees, cervical and lumbar pain during the last month. On clinical examination the patient was found to have tenderness of the cervical and the lumbar spine with great motion restriction. The blood tests revealed high erythrocyte sedimentation rate and C-reactive protein, abnormal liver function tests and a positive rheumatoid factor.