Sales of systemic anti-infective agents in Cyprus in comparison with four other European countries.

Objective: To determine the pattern of systemic antibiotic sales in Cyprus during the years 1990-1993 and 1996 and make a comparison with other four European countries.

Method: The Anatomical Therapeutic Chemical (ATC) classification and the Defined Daily Dose (DDD) methodology according to the WHO (World Health Organization) guidelines were employed and data in wholesales were used. The results were presented as DDD/1000 inhabitants/day and were compared with similar results from Sweden, Norway, Denmark and Greece.

Irradiation dose-response effects on angiogenesis and involvement of nitric oxide.

Background: Recent results implicate nitric oxide (NO) in the irradiation-induced perturbation of angiogenic mechanisms. We have previously shown, using the chick embryo chorioallantoic membrane (CAM) and a dose of 10 Gy, that the NO pathway is involved in X-ray-induced anti-angiogenicity. In the current study, we investigated the implication of NO in the effects of various doses (2-15 Gy) of irradiation on angiogenesis.

Effects of paclitaxel in combination with ionizing radiation on angiogenesis in the chick embryo chorioallantoic membrane. A radiobiological study.

Purpose: To investigate the combined effects of paclitaxel and single or fractionated doses of ionizing radiation on the angiogenesis process, using as a model the chick embryo choriallantoic membrane (CAM).

Material And Methods: Experiments were performed on 9-day CAM, when membranes were irradiated with various single or fractionated doses of X-rays, either alone or in combination with paclitaxel (6.4 micro g/disk).