Publications by authors named "Christopher W Humphreys"
Article Synopsis
- Multiple System Atrophy (MSA) is a deadly neurodegenerative disease linked to protein aggregation and shares similarities with Parkinson's disease; its complexity and fast progression make drug development challenging.
- Researchers have created a cohort of 69 carefully assessed MSA patients and are recruiting them into a unique clinical trial setup that tracks individual patient progress over time.
- The study includes extensive patient phenotyping, collection of biospecimens, and development of induced pluripotent stem cell (iPSC) models to enhance understanding of MSA and improve chances of successful therapies through personalized medicine.
Introduction: Pulmonary embolism is a common disorder that often requires extensive diagnostic testing. We hypothesized that an algorithmic approach to diagnosis of pulmonary embolism based upon clinical risk stratification and D-dimer testing would be less costly than a standard approach.
Materials And Methods: We constructed a decision tree based upon two published algorithms for diagnosing acute pulmonary embolism.
Objective: To determine the cost-effectiveness of the newer antiseptic and antibiotic-impregnated central venous catheters (CVCs) relative to uncoated CVCs and to each other.
Design: Decision model analysis of the cost and efficacy of CVCs coated with either chlorhexidine silver sulfadiazine (CSS) or rifampin-minocycline (RM) at preventing catheter-related bloodstream infections (CRBSIs). The primary outcome is the incremental cost (or savings) to prevent one additional CRBSI.