Publications by authors named "Christopher V Lisi"
Article Synopsis
- Otitis media (OM) involves infections and inflammation of the middle ear, potentially leading to chronic conditions like chronic suppurative otitis media (CSOM) with symptoms such as ear drum perforation and discharge.
- The study focuses on the behavior of a specific bacterium linked to CSOM and how it interacts with primary macrophages, revealing that the bacterium can enter and survive within these immune cells through specific cellular processes.
- Understanding how this bacterium avoids destruction by macrophages could help develop better treatments for OM by targeting its survival mechanisms.
Otitis media (OM) is an inflammation of the middle ear associated with infection. Despite appropriate therapy, acute OM (AOM) can progress to chronic suppurative OM (CSOM) associated with ear drum perforation and purulent discharge. The effusion prevents the middle ear ossicles from properly relaying sound vibrations from the ear drum to the oval window of the inner ear, causing conductive hearing loss.
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