Suitability and Early Clinical Outcomes of Corneal Donor Tissue in the 76-80-Year-Old Age Group.

Purpose: There is a significant global shortage of corneal donor tissue suitable for keratoplasty. One simple strategy for addressing this shortage is to increase the upper age limit for acceptable tissue over the current customary upper limit of age 75. We describe a pilot study completed at one eye bank procuring, processing, and distributing keratoplasty tissue from donors aged 76 to 80 years.

Dexamethasone Intracanalicular Insert versus Standard Topical Steroids for the Prophylaxis of Inflammation after Cataract Surgery.

Purpose: To compare the efficacy of an intracanalicular dexamethasone intracanalicular insert (DII) to a topical prednisolone acetate 1% taper for preventing breakthrough inflammation (iritis or cystoid macular edema [CME]) during the first postoperative month (POM1) after cataract surgery.

Design: Retrospective, nonrandomized comparative interventional study.

Methods: Patients received either DII or topical prednisolone acetate 1% eyedrops (control) during POM1.

Acute Calcific Band Keratopathy as an Adverse Effect of Recombinant Human Nerve Growth Factor (Cenegermin): A Multicenter Case Series.

Purpose: Cenegermin, (OXERVATE) a recently Food and Drug Administration-approved topical formulation of recombinant human nerve growth factor, has been used for the treatment of neurotrophic keratopathy (NK). Corneal deposits have been previously reported as a potential adverse effect; however, the clinical characteristics, visual significance, and treatment options have not been fully described. The purpose of this article is to better characterize corneal deposits occurring during treatment with cenegermin for neurotrophic keratopathy.

Recipient Factors Associated With Graft Detachment of a Subsequent Eye in Sequential Descemet Membrane Endothelial Keratoplasty.

Purpose: To evaluate the recipient factors associated with graft detachment in the subsequent eye of patients who underwent sequential Descemet membrane endothelial keratoplasty (DMEK).

Methods: A retrospective, consecutive case series with 158 eyes of 79 patients who underwent DMEK surgeries in both eyes between October 2013 and April 2019 for treatment of Fuchs endothelial dystrophy. The main outcome measure was the presence of graft detachment (any amount of detachment) at postoperative 1 week in the subsequent eye.

Endophthalmitis in Advanced Microbial Keratitis: Risk Factors and Examination Findings.

Purpose: To evaluate clinical and ultrasonographic findings associated with advanced microbial keratitis with concurrent endophthalmitis.

Methods: We performed a retrospective analytical study of patients with severe microbial keratitis who underwent ocular ultrasonography for possible endophthalmitis at our institution over a 5-year period. Ocular and medical history, ocular examination findings, microbiology results, and ultrasonographic features were collected.

Direct Injection of 5-Fluorouracil Improves Outcomes in Cicatrizing Conjunctival Disorders Secondary to Systemic Disease.

Purpose: Conjunctival cicatrizing conditions are vision threatening, with poor outcomes despite aggressive systemic therapy. This study tests the utility of serial injections of 5-fluorouracil (5-FU) into the fornices to treat conjunctival scarring in patients with ocular cicatricial pemphigoid or Stevens-Johnson syndrome/toxic epidermal necrolysis.

Methods: Retrospective cohort study.

Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) for Visual Rehabilitation in Limbal Stem Cell Deficiency.

Objectives: To evaluate the clinical outcomes of patients with limbal stem cell deficiency (LSCD) who were fitted with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) scleral device.

Methods: In this retrospective, interventional case series, we reviewed the charts of 31 eyes of 19 consecutive patients clinically diagnosed with LSCD who were evaluated for the PROSE device. Clinical data were reviewed before PROSE evaluation and at the last available follow-up.

Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus.

Background/aim: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO).

Methods: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center.

Results: The mean age of patients at the time of PKP was 68.

Teleophthalmic Approach for Detection of Corneal Diseases: Accuracy and Reliability.

Purpose: Corneal and anterior segment diseases cause most of the urgent visits to eye care professionals. We evaluated the diagnostic accuracy of detecting corneal diseases using external photographs from 2 portable cameras for telemedicine purposes.

Methods: This is a prospective study of adults with a clinical diagnosis of corneal pathology including corneal abrasions, ulcers, scars, and pterygia.

The effect of humidity and temperature on visual outcomes after myopic corneal laser refractive surgery.

Objective: To determine whether procedure room environmental conditions are associated with outcomes after myopic laser in situ keratomileusis (LASIK) or laser-assisted keratomileusis (LASEK).

Design: Retrospective chart review.

Participants: Eight hundred sixty-three eyes of 458 consecutive patients at a university-based academic practice.

Salzmann nodular degeneration associated with epithelial ingrowth after LASIK treated with superficial keratectomy.

A 41-year-old woman who underwent uncomplicated LASIK and two subsequent flap lifts for epithelial ingrowth of the right eye became progressively symptomatic with blurred vision, photophobia and foreign body sensation over the ensuing 5 years. Clinical examination of the right eye demonstrated extensive epithelial ingrowth around the flap periphery with overlying Salzmann nodules in the same distribution. Similar findings were not present in the left eye.

Subjective complaints after cataract surgery: common causes and management strategies.

Purpose Of Review: To describe the common causes of, and management strategies for, nonrefractive subjective visual complaints after cataract surgery.

Recent Findings: Over the past decade, clinical observations and ray-tracing models have greatly increased our understanding of positive and negative dysphotopsias after cataract surgery. The primary factor behind positive dysphotopsias is the use of high refractive index square-edge intraocular lenses (IOLs).

Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) scleral device compared to keratoplasty for the treatment of corneal ectasia.

Purpose: To compare the ocular characteristics and visual outcomes of eyes with corneal ectasia that were fitted with the Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) scleral device to those that underwent keratoplasty.

Design: Retrospective, comparative case series.

Methods: We reviewed the charts of consecutive patients with corneal ectasia that were evaluated for PROSE or underwent keratoplasty at our institution.

Prone positioning to facilitate graft adherence in the late postoperative period after descemet stripping automated endothelial keratoplasty.

Purpose: The aim of this study was to report the use of prone positioning to facilitate graft adherence in the late postoperative period after Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods: A 75-year-old woman with Fuchs dystrophy had repeated endothelial graft detachments after simultaneous DSAEK and phacoemulsification cataract surgery. Multiple attempts in the operating room to reposition the tissue, including placement of air into the anterior chamber, postoperative face-up positioning, and the use of new donor tissue, were unsuccessful.

Effect of tamsulosin on iris vasculature and morphology.

Purpose: To determine whether preoperative iris vasculature and morphology are altered in patients who have taken tamsulosin (Flomax).

Setting: Academic multispecialty practice.

Design: Case series.

Mechanisms for in-the-bag uveitis-glaucoma-hyphema syndrome.

We propose 2 mechanisms of uveitis-glaucoma-hyphema (UGH) syndrome in 2 patients with intracapsular or in-the-bag single-piece acrylic intraocular lenses (IOLs). In the first case, pseudophacodonesis secondary to zonular laxity from pseudoexfoliation syndrome caused chafing of the posterior iris by the square-edged haptic. In the second case, focal capsular fibrosis around the square-edged haptics combined with anteriorly rotated ciliary processes in plateau iris configuration caused points of chafing.

Influence of preoperative donor tissue characteristics on graft dislocation rate after Descemet stripping automated endothelial keratoplasty.

Purpose: To determine the influence of preoperative donor tissue characteristics on the graft dislocation rate after performing a Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods: We retrospectively analyzed the associations between donor tissue characteristics and graft dislocation rates for consecutive DSAEK surgeries performed in a 4-year period at a single institution.

Results: From June 2007 to June 2011, 64 (18%) of 355 eyes underwent a procedure for graft dislocation.

The association between femtosecond laser flap parameters and ocular aberrations after uncomplicated custom myopic LASIK.

Background: To investigate the association between femtosecond laser flap parameters, uncorrected distance visual acuity, and higher-order aberrations (HOA) after customized myopic LASIK.

Methods: Retrospective review of the charts of patients who underwent uncomplicated wavefront-guided customized myopic LASIK with flap creation using the femtosecond laser. Patients were stratified by intended flap thickness, and the change in HOA from preoperative to 3 months postoperative was compared.

Neodymium-yttrium-aluminum-garnet laser lysis of retained cortex after phacoemulsification cataract surgery.

Purpose: To describe the use of the neodymium-yttrium-aluminum-garnet (Nd:YAG) laser to lyse residual cortex after phacoemulsification cataract surgery and report the complications and outcomes of treatment.

Design: Interventional, retrospective case series.

Methods: Consecutive patients who underwent Nd:YAG laser treatment for residual cortex at the Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan were identified by review of laser logs from 2005 to 2011.

Incidence, occurrence rate, and characteristics of suture-related corneal infections after penetrating keratoplasty.

Purpose: To report the incidence, occurrence rate, and characteristics of suture-related infections after penetrating keratoplasty (PK).

Methods: Patients who underwent PK at our institution between January 1, 2002, and July 1, 2006, were cross-referenced with patients diagnosed with corneal infections between January 1, 2002, and July 1, 2007. All patient charts were reviewed retrospectively for occurrence of suture-related infections, duration of follow-up, and clinical characteristics.

Male breast carcinoma metastatic to the choroid: report of 3 cases and review of the literature.

Purpose: To describe breast cancer as a source of choroidal metastasis in men and highlight the diagnostic and treatment modalities.

Methods: Retrospective, noncomparative case series of male patients with breast cancer metastatic to the choroid. A literature review of the previously reported cases was also conducted.