Improved Detection of Clinically Significant Prostate Cancer With Software-assisted Systematic Biopsy Using MR/US Fusion in Patients With Negative Prostate MRI.

Objective: To compare detection rates of clinically significant prostate cancer (Gleason 7 or above) between standard transrectal ultrasound guided biopsy (TRUSGB) and software-assisted systematic biopsy (SASB) using magnetic resonance/ultrasound fusion in the setting of negative multiparametric magnetic resonance imaging (mpMRI) in biopsy-naïve patients.

Methods: We reviewed our prospectively maintained database of consecutive men that underwent prostate biopsy following mpMRI from September 2015 to December 2016. Patients with no prior biopsy (ie, biopsy naïve) whose mpMRI demonstrated no targetable lesions were included.