Paraneoplastic pemphigus without antibodies to desmoglein 1 and 3.

Paraneoplastic pemphigus is a severe autoimmune blistering disease presenting in the setting of underlying malignancy. Paraneoplastic pemphigus is associated with diffuse painful stomatitis throughout the oral cavity with extension to the lips. The cutaneous findings are varied and have been described as lichenoid, pemphigoid, and targetoid lesions.

Psoriasis mimicking mycosis fungoides clinically.

Psoriasis is a complex, chronic immune-mediated inflammatory disease that most commonly presents as well-demarcated erythematous plaques with micaceous scale, affecting roughly 3-4% of the US population [1-4]. Clinically, lesions are often well demarcated thick, scaly, erythematous plaques, characteristically located on the extensor surfaces, such as elbows and knees [1]. In most cases, clinical impression is sufficient to diagnose psoriasis.

Petrified Ear - A Case Report and Review of the Literature.

Petrified ear is the transformation of normal, flexibleauricular cartilage into rigid, immobile auricularcartilage due to abnormal calcification or ossification.Etiologies of petrified ear include tissue injury,systemic endocrine diseases, congenital disorders,or petrified ear of unknown origin. We present a caseof a 69-year-old male with a one-month history ofnon-painful rigidity of the right ear that was found tohave petrified ear of unknown etiology confirmed byradiography.

Integrin α2β1 mediates tyrosine phosphorylation of vascular endothelial cadherin induced by invasive breast cancer cells.

The molecular mechanisms that regulate the endothelial response during transendothelial migration (TEM) of invasive cancer cells remain elusive. Tyrosine phosphorylation of vascular endothelial cadherin (VE-cad) has been implicated in the disruption of endothelial cell adherens junctions and in the diapedesis of metastatic cancer cells. We sought to determine the signaling mechanisms underlying the disruption of endothelial adherens junctions after the attachment of invasive breast cancer cells.

Joint contact characteristics in agility total ankle arthroplasty.

High component contact pressures in total joint prostheses can lead to particle wear debris and prosthesis loosening. The contact pressures in the Agility total ankle prosthesis have not been investigated. In the current study, a cadaveric model was used to evaluate contact characteristics (average contact area, contact pressure, and contact peak pressures) for the Agility total ankle system.

Proprioception of the knee before and after anterior cruciate ligament reconstruction.

Purpose: The purpose of this study was to determine, first, if there is measurable deficit in proprioception in an anterior cruciate ligament (ACL)-deficient knee, either compared to the contralateral knee or external controls; second, if this deficit, if present, improves after ACL reconstruction; and third, if improvement occurs, what the time course of improvement is.

Type Of Study: Prospective cohort study.

Methods: Patients undergoing ACL reconstruction at the University of Chicago, demonstrating a full and painless range of motion and no other knee ligament injury or history of previous knee surgery, were eligible.

Absorbable implants in fracture management.

The use of absorbable implants has been studied extensively in the clinic and the laboratory. The limitations of absorbable implants are now well-known and include a finite life span and strength profile, the possible development of an inflammatory response, and their limitation to use in fractures that do not require traditional compression techniques. Advantages of these implants include the lack of necessity for removal at a later date, which has cost savings potential, their ease of use, and their strength, which may be sufficient for healing in certain situations.

Arthroscopic arthrodesis of the ankle, subtalar, and first metatarsophalangeal joint.

Arthroscopy of the foot and ankle should become part of the armamentarium of the foot and ankle surgeon. An arthroscopic fusion procedure of the ankle, subtalar, or first MTP joint is a viable alternative in certain patients. Appropriately selected patients (i.