Publications by authors named "Christopher Spahn"
Article Synopsis
- Computer-based analysis assessed motility in transgenic GMC101 nematodes expressing human amyloid-β (Aβ) to evaluate the impact of caprylic acid (CA) on proteotoxicity and Aβ aggregation.
- CA enhanced nematode motility and reduced Aβ aggregation, with gene knockdowns showing that β-oxidation of fatty acids is critical for CA's effectiveness, while other metabolic pathways were not as affected.
- The positive effects of CA were linked to improved mitochondrial function, highlighting its potential as an alternative energy source in conditions like Alzheimer’s disease where glucose metabolism is impaired.
