Publications by authors named "Christopher S. Ogilvy"

Objective: While the relationship between smoking and subarachnoid hemorrhage is well established, data regarding the probability of detecting unruptured intracranial aneurysms (UIAs) in smokers remain sparse. The aim of this systematic review and meta-analysis is to provide a comprehensive understanding of the relationship between smoking and the likelihood of identifying UIAs in healthy asymptomatic patients who underwent brain imaging for indications unrelated to UIAs.

Methods: A systematic review was conducted following the PRISMA guidelines.

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Objective: Endovascular intracranial aneurysm (IA) management has significantly evolved over the last 2 decades. Despite these advancements, the aneurysm recanalization rate after coil embolization remains a concern. Statins have been found to affect vascular repair and remodeling; therefore, the authors hypothesized that patients receiving statin therapy at the time of coil embolization would have lower aneurysm recurrence and retreatment rates compared with patients not receiving statin therapy.

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Anterior choroidal artery (AChA) aneurysms represent 2-5% of intracranial aneurysms. The proximity of the origin of the AChA to the aneurysm neck poses a risk of thromboembolic complications following treatment. AChA occlusion can result in significant neurological deficits.

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Article Synopsis
  • - The study aimed to analyze stroke-related outcomes between Moyamoya syndrome (MMS) subgroups and Moyamoya disease (MMD) patients using propensity score matching (PSM) to provide direct comparisons.
  • - Researchers analyzed a national database from 2011-2020, focusing on patients with MMD and specific comorbidities (sickle-cell disease, Down syndrome, and neurofibromatosis), and matched them to control for stroke risk factors.
  • - Results indicated that patients with MMS related to sickle-cell disease had significantly lower rates of ischemic strokes, hemorrhagic strokes, and transient ischemic attacks compared to those with MMD only, while no significant differences were found in the MMS
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Background: Socioeconomic status has historically influenced traumatic brain injury (TBI) outcomes, yet pediatric TBI disparities remain understudied. We aimed to analyze the National Inpatient Sample database for socioeconomic disparities in the outcomes of pediatric TBI patients.

Methods: The National Inpatient Sample from 2011 to 2020 was retrospectively analyzed for pediatric TBI patients.

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Objectives: Moyamoya disease (MMD) is a cerebrovascular disorder marked by the progressive steno-occlusion of the bilateral internal carotid arteries and the formation of abnormal collateral vessel networks at the base of the brain. Previous studies have attempted to identify risk factors predictive of postoperative complications to improve patient management. This study aims to identify pretreatment factors associated with post-bypass symptomatic strokes in MMD patients.

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Background: Residual intracranial aneurysms post-clipping or coiling pose a poorly established risk of rupture. Computational fluid dynamic (CFD) offers insights into hemodynamic changes following such interventions. This study aims to assess hemodynamic parameters in residual aneurysms pre- and post-treatment with surgical clips or coils using CFD.

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Background And Objectives: Computational fluid dynamics has advanced our knowledge of the pathogenesis of intracranial aneurysms and the dynamic changes observed after treatment. Herein, we analyze hemodynamic changes throughout the intervention stages for ruptured posterior communicating artery (PComA) aneurysms, treated with acute coiling and delayed flow diversion (FD).

Methods: We performed a retrospective analysis of ruptured PComA aneurysms treated with the acute coiling and delayed FD strategy between June 2013 to November 2022, using 3-dimensional reconstructions of digital subtraction angiographies.

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Background And Objectives: Multiple preferences exist for embolic materials selection in middle meningeal artery embolization (MMAE) for chronic subdural hematoma with limited comparative literature data. Herein, we compare different embolic materials.

Methods: Consecutive patients undergoing MMAE for chronic subdural hematoma at 14 North-American centers (2018-2023) were classified into 3 groups: (a) particles, (b) Onyx, (c) n-butyl cyanoacrylate (n-BCA).

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Background And Objectives: Moyamoya disease (MMD) is characterized by progressive steno-occlusion of the internal carotid arteries, leading to compensatory collateral vessel formation. The optimal surgical approach for MMD remains debated, with bilateral revascularization potentially offering more comprehensive protection but involving more extensive surgery compared to unilateral revascularization. This study aims to compare bilateral revascularization and unilateral revascularization short-term safety profile in the treatment of MMD.

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Background: Multiple factors have been proposed to affect the vessel ingrowth from the superficial temporal artery (STA) after Encephalo-Duro-Arterio-Synangiosis (EDAS).

Methods: This retrospective single-center analyses included patients with Moyamoya Disease (MMD) undergoing EDAS from January 1st, 2013, to December 31st, 2023. Evaluated variables included demographic characteristics, clinical presentation, technical details, modified Rankin Scale (mRS) scores, and radiographic outcomes.

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Background: The plasticity of the Circle of Willis represents an underexplored yet intriguing dimension of vascular anatomy in cerebrovascular disorders. We outline distinct patterns of change in response to aneurysm treatment using flow diversion (FD) after covering major branches.

Methods: Retrospective analysis of digital subtraction angiographies from intracranial aneurysms treated with FD from 2013 to 2023.

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Background: Arteriovenous malformations (AVMs) are uncommon cerebral lesions that can cause significant neurological complications. Surgical resection is the gold standard for treatment, but endovascular embolization and stereotactic radiosurgery (SRS) are viable alternatives.

Objective: To compare the outcomes of endovascular embolization versus SRS in the treatment of AVMs with Spetzler-Martin grades I-III.

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Objective: As endovascular interventions become safer and their use more prevalent for treating extracranial pseudoaneurysms, fewer pseudoaneurysms are treated with medical therapy alone. This study aimed to assess the indications for intervention and the safety of medical management.

Methods: A dual-center retrospective analysis was conducted on patients diagnosed with extracranial carotid and vertebral pseudoaneurysms between December 2006 and June 2023.

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Article Synopsis
  • Chronic subdural hemorrhage (cSDH) is a common neurosurgical condition, and this systematic review aimed to identify risk factors for seizures following its treatment.* -
  • The review analyzed 18 studies with nearly 5000 patients, finding a 10% overall seizure incidence after treatment, with lower risks associated with burr hole surgery compared to craniotomy.* -
  • The findings suggest a need for standardized reporting and more comparative research to better understand seizure risks post-cSDH treatment, particularly regarding the effectiveness of prophylactic antiepileptic medications.*
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Article Synopsis
  • - Moyamoya disease (MMD) is a rare brain disorder that causes narrowing of blood vessels, often accompanied by high blood pressure, which complicates the condition's outcomes; this study compares MMD patients with and without hypertension.
  • - A total of 598 MMD patients were analyzed from multiple institutions, with hypertensive (292) and non-hypertensive (306) groups evaluated for clinical characteristics and outcomes using statistical adjustments to account for differences in their backgrounds.
  • - Results indicated that although hypertensive patients showed higher rates of certain risk factors (like diabetes and smoking) and higher stroke rates before adjustments, post-matching analysis revealed no significant differences in stroke rates or recovery outcomes between the two groups, suggesting effective
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Background: The Matsushima grade has traditionally been used to evaluate vessel ingrowth from the superficial temporal artery after encephalo-duro-arterio-synangiosis (EDAS) for Moyamoya disease (MMD) patients. However, this grading is subjective and prone to measurement variability. Herein, we propose the orbital grading system quantifying leptomeningeal and burr hole-related vessel-ingrowth from the superficial temporal artery and/or middle meningeal artery to the middle and anterior cerebral arteries post EDAS in MMD patients.

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Background Context: Our recent studies indicated that a high-riding vertebral artery (HRVA) is a common variant posing a risk of injuring the vessel during C2 instrumentation. However, several different types fit in the current definition of HRVA, which may require a different strategy for C2 screw placement.

Purpose: To classify HRVA and provide a clinical aid for preoperative planning of C2 instrumentation.

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Dual antiplatelet therapy (DAPT) use is the standard of practice after flow diversion (FD) for intracranial aneurysms (IAs). Yet, no consensus exists in the literature regarding the optimal regimen. Certain institutions utilize various platelet function testing (PFT) to assess patient responsiveness to DAPT.

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Article Synopsis
  • Thromboembolic (TE) events, which can arise even with proper dual antiplatelet therapy, are serious complications following flow diversion (FD) procedures used to treat aneurysms, leading to significant morbidity and mortality.
  • A study was conducted on 651 FD procedures in 591 patients from 2013 to 2023, revealing a TE event rate of 5.8%, with permanent deficits in 20 patients and 4 fatalities linked to vascular occlusions.
  • Factors such as aspirin resistance, age, and aneurysm characteristics were identified as predictors for the occurrence of TE events, particularly highlighting the high morbidity associated with large-vessel occlusions in the middle cerebral artery.
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Background And Objective: Surgery is the mainstay of stroke prevention in patients with symptomatic moyamoya disease (MMD). We present the results of a single-center retrospective study of indirect revascularization surgery for adult MMD, emphasizing angiographic outcomes, including dilation of the superficial temporal artery and formation of new collaterals.

Methods: A prospectively maintained database of procedures performed for MMD was reviewed.

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Objective: Anterior choroidal artery (AChA) aneurysms account for 2%-5% of all intracranial aneurysms. Treatment considerations include microsurgical clipping, flow diversion, or coiling with or without adjunctive devices. AChA aneurysms pose challenges in treatment due to the origination of the aneurysm from the origin or proximal segment of the AChA.

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Background: Factors impacting the rate of aneurysm occlusion after flow diversion (FD) have been well described in the literature. In this article, we sought to evaluate those variables to develop and validate a scoring system predicting aneurysm incomplete occlusion after FD.

Methods: Retrospective review of patients with intracranial aneurysms treated with FD at a single institution between March 2013 and March 2023.

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Cerebral bypass surgery is one of the most complex and elegant procedures in neurosurgery. It involves several meticulous steps that test the skills of even the most prepared neurosurgeons. This surgery has transcended its traditional role in arterial stenosis and atherosclerosis, expanding its applications to include flow preservation techniques for complex conditions such as aneurysms, tumors, and vascular malformations.

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