Publications by authors named "Christopher Rousso"
Sci Transl Med
January 2018
Article Synopsis
- Resistance to oncolytic virotherapy often happens when tumor cells can't be infected by the virus, leading to treatment failure.
- Dimethyl fumarate (DMF), used for psoriasis and multiple sclerosis, shows potential anticancer effects by enhancing viral infection in cancer cell lines and human tumor samples.
- DMF works by inhibiting type I interferon production and affecting the transcription factor NF-κB, leading to better therapeutic results in resistant tumor models and demonstrating the benefits of repurposing FDA-approved drugs for cancer treatment.
Article Synopsis
- * A new strategy combines OVs with vanadium-based protein tyrosine phosphatase inhibitors, which enhances OV infection and boosts antitumor effects in resistant tumor cell lines and models.
- * This combination alters the immune response from a protective to a pro-inflammatory type, improving viral spread and cancer cell killing, and suggests a promising direction for better immunotherapy approaches.
