Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes.

Background: Potassium channels (KCa3.1; Kv1.3; Kir2.

Preoperative sedentary behavior is neither a risk factor for perioperative neurocognitive disorders nor associated with an increase in peripheral inflammation, a prospective observational cohort study.

Background: Surgical interventions result in a postoperative rise in circulating inflammatory cytokines and high molecular group box protein 1 (HMGB1). Herein, the impact of a sedentary lifestyle and other age-related factors on the development of perioperative neurocognitive disorders (PND) following non-cardiac surgical procedures was assessed in an older (55-75 years-old) surgical population.

Methods: Prior to surgery, patients were asked questions regarding their sedentary behavior and daily habits.