Publications by authors named "Christopher R Sedlak"
Detection of cancer early, when it is most treatable, remains a significant challenge because of the lack of diagnostic methods sufficiently sensitive to detect nascent tumors. Early-stage tumors are small relative to their tissue of origin, heterogeneous, and infrequently manifest in clinical symptoms. The detection of early-stage tumors is challenging given the lack of tumor-specific indicators (ie, protein biomarkers, circulating tumor DNA) to enable detection using a noninvasive diagnostic assay.
View Article and Find Full Text PDFArticle Synopsis
- - The Mercy Halo Ovarian Cancer Test (OC Test) is a new screening method that detects ovarian cancer by analyzing proteins found on tumor-associated extracellular vesicles in blood, aiming for both high sensitivity and specificity.
- - In a study involving 397 women, the OC Test showed impressive results: 97% specificity and sensitivity for high-grade serous carcinoma (HGSC), and it also identified 73.5% of non-HGSC ovarian cancer cases.
- - Compared to the conventional cancer antigen 125, the OC Test resulted in fewer false positives among patients with non-cancerous conditions, indicating its potential for effective ovarian cancer screening.