Publications by authors named "Christopher R Robles"
Article Synopsis
- - Pluripotent stem cells (PSCs) are being explored as a source for off-the-shelf T cell immunotherapies, but their differentiation into mature T cells can lead to complications if not properly managed.
- - Researchers successfully generated mature T cells from genetically edited PSCs that lack specific T cell receptors (TCRs) and class I major histocompatibility complexes, using a combination of human and murine cells for T cell maturation.
- - The study found that these edited T cells demonstrated significantly improved tumor control in mouse models compared to those with intact TCRs, suggesting a promising approach for enhancing T cell immunotherapies derived from PSCs.
The genetic variants introduced into the ancestors of modern humans from interbreeding with Neanderthals have been suggested to contribute an unexpected extent to complex human traits. However, testing this hypothesis has been challenging due to the idiosyncratic population genetic properties of introgressed variants. We developed rigorous methods to assess the contribution of introgressed Neanderthal variants to heritable trait variation and applied these methods to analyze 235,592 introgressed Neanderthal variants and 96 distinct phenotypes measured in about 300,000 unrelated white British individuals in the UK Biobank.
View Article and Find Full Text PDFIdentifying gene-environment interactions (GxEs) contributing to human cardiometabolic disorders is challenging. Here we apply a reverse GxE candidate search by deriving candidate variants from promoter-enhancer interactions that respond to dietary fatty acid challenge through altered chromatin accessibility in human primary adipocytes. We then test all variants residing in the lipid-responsive open chromatin sites within adipocyte promoter-enhancer contacts for interaction effects between the genotype and dietary saturated fat intake on body mass index (BMI) in the UK Biobank.
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