Histotripsy fractionation of prostate tissue: local effects and systemic response in a canine model.

Purpose: Histotripsy is an extracorporeal ultrasound technology that uses cavitational mechanisms to produce nonthermal tissue destruction. Previously we reported the feasibility of histotripsy for prostate tissue fractionation and immediate debulking. In this study we characterized the local effects and systemic response after histotripsy treatment of prostate tissue in an in vivo canine model.

Acoustic access to the prostate for extracorporeal ultrasound ablation.

This study aimed to measure acoustic access to the prostate for extracorporeal ultrasound ablation. Both transabdominal and transperineal approaches were considered. The objective was to measure the size and shape of the aperture available for unobstructed targeting of the prostate.

Prostate histotripsy in an anticoagulated model.

Objectives: To further explore the phenomenon of minimal bleeding after histotripsy by performing extensive prostate histotripsy treatments in anticoagulated canines. Histotripsy is a noninvasive ultrasound technology which induces microbubble formation (cavitation) within tissues producing mechanical tissue fractionation. During initial in vivo feasibility canine studies of prostate ablation, minimal hematuria was observed.

Histotripsy of the prostate: dose effects in a chronic canine model.

Objectives: To develop the technique of histotripsy ultrasound therapy as a noninvasive treatment for benign prostatic hyperplasia and to examine the histotripsy dose-tissue response effect over time to provide an insight for treatment optimization. We have previously demonstrated the feasibility of prostate histotripsy fractionation in a canine model.

Methods: Various doses of histotripsy were applied transabdominally to the prostates of 20 canine subjects.