Publications by authors named "Christopher Proffitt"
Article Synopsis
- The immune system has the potential to control cancer, but the role of certain immune sensors in cancer aggressiveness, specifically NLRC4, remains largely unexplored in humans.
- This study found that decreased levels of NLRC4 in colorectal cancer (CRC) cells are linked to poorer immune cell infiltration and worse patient outcomes, indicating its importance in tumor progression.
- Enhancing NLRC4 expression in CRC cells led to immune reprogramming that improved the function of immune cells, suggesting that targeting NLRC4 could provide a new approach to boosting antitumor responses in various types of carcinoma.
