Publications by authors named "Christopher Nutter"
Article Synopsis
- Aging slows down the activation and increases the death of skeletal muscle stem cells (MuSCs), which leads to poor muscle repair.
- Researchers used a multiomics approach, single-cell analysis, and functional tests to compare MuSCs from young and old mice, revealing that glutathione (GSH) metabolism is disrupted in older cells.
- They discovered that older MuSCs form two distinct groups based on their GSH functionality and identified a mechanism involving NRF2 and NF-κB that maintains this division, suggesting that manipulating GSH levels could help reverse aging effects in MuSCs.
NLRP3 inhibition improves maternal hypertension, inflammation, and vascular dysfunction in response to placental ischemia.
Am J Physiol Regul Integr Comp Physiol
April 2023
Preeclampsia (PE) is a pregnancy-specific hypertensive disorder with end-organ damage that presents after 20 wk of gestation. PE pathophysiology often includes vascular dysfunction and increased inflammation that continues to damage patient health even after PE resolves. Currently, there is no cure for PE beyond delivery of the fetal-placental unit.
View Article and Find Full Text PDFShort-term fasting is beneficial for the regeneration of multiple tissue types. However, the effects of fasting on muscle regeneration are largely unknown. Here, we report that fasting slows muscle repair both immediately after the conclusion of fasting as well as after multiple days of refeeding.
View Article and Find Full Text PDFOccidiofungin is produced by the soil bacterium MS14 and is structurally similar or identical to the burkholdines, xylocandins, and cepacidines. This study identified the primary cellular target of occidiofungin, which was determined to be actin. The modification of occidiofungin with a functional alkyne group enabled affinity purification assays and localization studies in yeast.
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