Publications by authors named "Christopher Mittlelhaeuser"
Article Synopsis
- The analgesic effects of muscarinic M receptor agonists have been supported by pharmacological studies and mouse models, showing that knockout (KO) of these receptors increases pain response.
- Two new positive allosteric modulators, Compounds 1 and 2, reduced pain-related behaviors in rodent models, with their effects being specific to mice with intact M receptors.
- Compound 1 exhibited spinal and central nervous system involvement in pain modulation without affecting opioid pathways, suggesting potential for effective pain management with safety considerations.
