Publications by authors named "Christopher Mascio"

Background: Recent approval of transcatheter aortic valve replacement (TAVR) in patients at lower risk profiles has resulted in a real-world expansion in patients with Bicuspid Aortic Valves (BAV), otherwise excluded from trials comparing TAVR to surgical aortic valve replacement (SAVR). Compare perioperative and longitudinal outcomes between BAV patients undergoing TAVR vs. SAVR.

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Objective: To evaluate the relationship between center volume and inpatient mortality after inter-hospital transfer among patients undergoing pediatric cardiac surgery using contemporary real-world data.

Methods: The Kids' Inpatient Database (KID) was queried for cardiopulmonary bypass (CPB) cases (CPB) for years 2016 and 2019. Hospitals were divided into three groups based on terciles of volume: "low": ≤103 cases/year, "mid":104-194 cases/year, and "high": >194 cases/year.

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Article Synopsis
  • Neonates with symptomatic tetralogy of Fallot (sTOF) often require early surgical intervention, which can involve either staged repair (SR) or primary repair (PR), but both strategies expose them to low-dose ionizing radiation that may raise cancer risk.
  • This study analyzed the cumulative radiation exposure and lifetime attributable risk (LAR) of cancer in sTOF patients who underwent either SR or PR, using data from 242 neonates across multiple centers.
  • Results showed that SR resulted in significantly higher radiation exposure compared to PR and highlighted an increased LAR of cancer, particularly for females, emphasizing the need to consider radiation risk when choosing treatment options for this vulnerable group.*
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Background: Despite prospective randomized evidence supporting concomitant treatment of atrial fibrillation (AF) during mitral valve (MV) surgery, variation in surgical management of AF remains. We assessed longitudinal outcomes after surgical treatment of persistent or paroxysmal AF during MV surgery in Medicare beneficiaries.

Methods: All Medicare beneficiaries with a diagnosis of AF undergoing MV surgery (2018-2020) were evaluated.

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Enterobacter cloacae cardiac implantable electronic device infections are rare but can be associated with significant morbidity and mortality. We report an 11-year-old female with Enterobacter cloacae infection of a dual-chamber transvenous pacemaker pocket. The report is supplemented by a comprehensive review of the literature on Enterobacter cloacae cardiac implantable electronic device infections.

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Article Synopsis
  • The study aimed to compare the outcomes of neonates with symptomatic tetralogy of Fallot (TOF) based on whether they had a ductus arteriosus (DA) or absent DA (ADA).
  • Researchers conducted a retrospective multi-center study involving 519 neonates to assess the risks of death and need for reintervention, focusing on ADA and critically deficient pulmonary blood flow (CDPBF).
  • Findings indicated that neonates with ADA faced a significantly higher mortality risk compared to those with DA, highlighting the rare but critical nature of CDPBF among these patients.
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Objective: Recent approval of transcatheter aortic valve replacement (TAVR) in patients at low surgical risk has resulted in a rapid real-world expansion of TAVR in patients not otherwise examined in recent low-risk trials. We sought to evaluate the outcomes of surgical aortic valve replacement (SAVR) versus TAVR in low-risk Medicare beneficiaries.

Methods: Using the US Centers for Medicare and Medicaid Services claims database, we evaluated all beneficiaries undergoing isolated SAVR (n = 33,210) or TAVR (n = 77,885) (2018-2020).

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Article Synopsis
  • - The study aimed to compare the Hybrid and Norwood procedures for treating patients with hypoplastic left heart syndrome and assess their impact on hospital mortality from 1984 to 2022.
  • - Over the years, 1,899 patients underwent the Norwood procedure while 82 had the Hybrid procedure, with Hybrid usage rising to 30% by the last analysis period, but it was linked to higher hospital mortality after adjusting for risk factors.
  • - Despite the increased adoption of the Hybrid procedure, overall mortality rates have remained stable, suggesting the need for further evaluation of the Hybrid approach in terms of its efficacy.
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Background: Societal guidelines support atrial fibrillation (AF) treatment during surgical aortic valve replacement (SAVR). Recently, many patients with AF at low to intermediate risk are managed by transcatheter aortic valve replacement (TAVR). Therefore, we evaluated longitudinal outcomes in these populations.

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Background: Lower institutional volume has been associated with inferior pediatric cardiac surgery outcomes. This study explored the variation in mortality rates among low-, mid-, and high-volume hospitals performing pediatric cardiac surgery in the United States.

Methods: The Kids' Inpatient Database was explored for the years 2016 and 2019.

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mutations are associated with childhood epilepsy, developmental delay, and vascular malformations. We report a child with a likely pathogenic mutation (c.1885A>C, p.

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Background: Infants with hypoplastic left heart syndrome (HLHS) or a variant are at risk of ventricular dysfunction (VD) and atrioventricular valve regurgitation (AVVR) prior to superior cavopulmonary connection (SCPC). Although the impact of these complications in isolation has been described, their effect in combination on attrition is poorly defined.

Methods: A retrospective observational study of patients with HLHS or variants undergoing a Norwood procedure between 2008 and 2020 at a single center was performed.

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Background: Societal guidelines support concomitant management of atrial fibrillation (AF) in patients undergoing cardiac surgery. To assess real-world adoption and outcomes, this study evaluated Medicare beneficiaries with AF who underwent isolated coronary artery bypass grafting (CABG) with surgical ablation (SA) or left atrial appendage obliteration (LAAO) or both procedures in combination (SA + LAAO).

Methods: The US Centers for Medicare & Medicaid Services inpatient claims database identified all patients with AF who underwent isolated CABG from 2018 to 2020.

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We report a 5-year-old girl with transient complete atrioventricular (AV) block following surgical closure of a symptomatic conoventricular ventricular septal defect (VSD) which recovered on post-operative day 9. She later presented with exertional dizziness and fatigue. While congenital cardiac defect repairs are occasionally complicated by complete heart block, this patient was found to have intra-Hisian Wenckebach which is rare in the pediatric population and can be very difficult to discern from surface electrocardiograms and by Holter monitoring.

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Ganglioneuroma is a benign tumor requiring subtotal resection as a primary mode of treatment. There are several surgical approaches. A giant ganglioneuroma of the chest cavity may be approached via a clamshell thoracotomy.

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Article Synopsis
  • - The study analyzed neonates with symptomatic tetralogy of Fallot (sTOF) to examine how hypoplastic pulmonary arteries (hPA) impact survival and treatment outcomes, reviewing data from 2005 to 2017 on 542 cases.
  • - Results showed that while reintervention was more common in the hPA group, survival rates and mortality did not differ significantly between those with hPA and those with normal pulmonary arteries.
  • - Notably, the hPA cohort experienced better pulmonary artery growth after one year, suggesting that having hPA does not negatively affect the overall outcomes for neonates with sTOF.
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Background: There is a significant incidence of pre-Fontan attrition-defined as failure to undergo Fontan completion-after superior cavopulmonary connection. This study investigated the impact of at least moderate ventricular dysfunction (VD) and atrioventricular valve regurgitation (AVVR) on pre-Fontan attrition.

Methods: This single-center retrospective cohort study included all infants who underwent Norwood palliation from 2008 to 2020 and subsequently underwent superior cavopulmonary connection.

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Background Intensive monitoring has been associated with a lower death rate between the Norwood operation and superior cavopulmonary connection, possibly due to early identification and effective treatment of residual anatomic lesions like recoarctation before lasting harm occurs. Methods and Results Neonates undergoing a Norwood operation and receiving interstage care at a single center between January 1, 2005, and September 18, 2020, were studied. In those with recoarctation, we evaluated association of era ([1] preinterstage monitoring, [2] a transitional phase, [3] current era) and likelihood of hemodynamic compromise (progression to moderate or greater ventricular dysfunction/atrioventricular valve regurgitation, initiation/escalation of vasoactive/respiratory support, cardiac arrest preceding catheterization, or interstage death with recoarctation on autopsy).

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Background: Interpretation of recent alterations to the guideline priority of coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for multivessel disease contests historical data and practice. To reevaluate contemporary outcomes, a large contemporary analysis was conducted comparing CABG with multivessel PCI among Medicare beneficiaries.

Methods: The United States Centers for Medicare and Medicaid Services database was evaluated all beneficiaries with acute coronary syndrome undergoing isolated CABG or multivessel PCI (2018-2020).

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Objectives: Aortic valve repair can be limited by inadequate leaflet tissue for proper coaptation. Various kinds of pericardium have been used for cusp augmentation, but most have failed because of tissue degeneration. A more durable leaflet substitute is needed.

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Objective: Societal guidelines support the concomitant surgical ablation of atrial fibrillation in patients undergoing cardiac surgery. Recent evidence has highlighted the stroke reduction of left atrial appendage obliteration with or without surgical ablation in similar populations. To inform clinical decision-making, we evaluated real-world outcomes of patients with atrial fibrillation undergoing cardiac surgery by comparing no atrial fibrillation management with left atrial appendage obliteration alone versus surgical ablation + left atrial appendage obliteration.

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Background Infants with congenital heart disease (CHD) are at risk for white matter injury (WMI) before neonatal heart surgery. Better knowledge of the causes of preoperative WMI may provide insights into interventions that improve neurodevelopmental outcomes in these patients. Methods and Results A prospective single-center study of preoperative WMI in neonates with CHD recorded data on primary cardiac diagnosis, maternal-fetal environment (MFE), delivery type, subject anthropometrics, and preoperative care.

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Article Synopsis
  • Neonates with tetralogy of Fallot and pulmonary atresia rely on the arterial duct for blood flow and require early surgical intervention, either through primary repair or staged repair, but the best method remains unclear.* -
  • A review of 282 neonates revealed that while mortality rates were similar between primary and staged repair, those undergoing staged repair faced greater early reintervention rates and had larger conduit sizes during complete repair.* -
  • Primary repair generally showed better outcomes in terms of lower complications, shorter hospital stays, and better growth of the right pulmonary artery, while staged repair is more common in patients with greater risk factors such as DiGeorge syndrome.*
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Background: The Society of Thoracic Surgeons (STS) Congenital Heart Surgery Database was queried to document variation of patient characteristics, procedure types, and programmatic case-mix.

Methods: All index cardiac operations in patients less than 18 years of age in the STS Congenital Heart Surgery Database (July 2016 to June 2020) were eligible for inclusion except patients weighing ≤2.5 kg undergoing isolated patent ductus arteriosus closure.

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