Separation of plastic wastes using froth flotation - An overview.

Despite various initiatives and efforts, plastic solid waste (PSW) has become a major global problem due to decades of relentless use of plastics. Since non-biodegradable plastics can persist in the environment for hundreds of years, threatening animal and human life, discarding them into the environment is not a viable option. Plastic recycling is a critical research area that requires urgent attention since less than 10% of the seven billion tons of globally generated plastic waste has been recycled so far.

A review of reagents applied to rare-earth mineral flotation.

The rare-earth elements (REE), which encompass the fifteen metallic elements of the lanthanoid series of the periodic table, yttrium and occasionally scandium, have gained enormous public, economic and scientific attention in recent years. These elements, which have been found in over 250 minerals, are of high economic and strategic importance to many high-technology industries. As such they have been designated as critical materials by several countries and many new deposits are being developed.

Methotrexate sensitizes drug-resistant metastatic melanoma cells to V600E inhibitors dabrafenib and encorafenib.

Acquired resistance of metastatic melanoma (MM) tumors to V600E inhibitors (BRAFi's) is commonplace in the clinic. Habitual relapse of patients contributes to <20% 5-year survival rates in MM. We previously identified serine synthesis as a critical detrminant of late-stage cancer cell resistance to BRAFi's.

Identification of the Serine Biosynthesis Pathway as a Critical Component of BRAF Inhibitor Resistance of Melanoma, Pancreatic, and Non-Small Cell Lung Cancer Cells.

Metastatic melanoma cells commonly acquire resistance to V600E inhibitors (BRAFi). In this study, we identified serine biosynthesis as a critical mechanism of resistance. Proteomic assays revealed differential protein expression of serine biosynthetic enzymes PHGDH, PSPH, and PSAT1 following vemurafenib (BRAFi) treatment in sensitive versus acquired resistant melanoma cells.

An alpha-(1,4)-amylase is essential for alpha-(1,3)-glucan production and virulence in Histoplasma capsulatum.

Histoplasma capsulatum is a dimorphic fungus that causes respiratory and systemic disease and is capable of surviving and replicating within macrophages. The virulence of Histoplasma has been linked to cell wall alpha-(1,3)-glucan; however, the role of this polysaccharide during infection, its organization within the cell wall, and its synthesis and regulation remain poorly understood. To identify genes involved in the biosynthesis of alpha-(1,3)-glucan, we employed a forward genetics strategy to isolate physically marked mutants with reduced alpha-(1,3)-glucan.