Adaptation of the human Cell Line Activation Test (h-CLAT) to Animal-Product-Free Conditions.

Skin sensitisers are substances that can elicit allergic responses following skin contact and the process by which this occurs is described as skin sensitisation. Skin sensitisation is defined as a series of key events, that form an adverse outcome pathway (AOP). Key event three in the AOP is dendritic cell activation that can be modelled by the human Cell Line Activation Test (h-CLAT) and is typified by changes in cell surface markers CD54 and CD86 in dendritic cells.

Adaptation of the KeratinoSens™ skin sensitization test to animal-product-free cell culture.

Skin sensitization is the process by which a substance induces an allergic reaction following skin contact. The process has been described as an adverse outcome pathway (AOP), including several key events, from skin penetration and covalent protein binding, to keratinocyte activation, dendritic cell activation and T-lymphocyte proliferation. The in vitro assay KeratinoSens™ measures the activation of keratinocytes.

Image dependency in the recognition of newly learnt faces.

Research investigating the effect of lighting and viewpoint changes on unfamiliar and newly learnt faces has revealed that such recognition is highly image dependent and that changes in either of these leads to poor recognition accuracy. Three experiments are reported to extend these findings by examining the effect of apparent age on the recognition of newly learnt faces. Experiment 1 investigated the ability to generalize to novel ages of a face after learning a single image.

Oxidative Stress Alters the Morphology and Toxicity of Aortic Medial Amyloid.

The aggregation and fibril deposition of amyloid proteins have been implicated in a range of neurodegenerative and vascular diseases, and yet the underlying molecular mechanisms are poorly understood. Here, we use a combination of cell-based assays, biophysical analysis, and atomic force microscopy to investigate the potential involvement of oxidative stress in aortic medial amyloid (AMA) pathogenesis and deposition. We show that medin, the main constituent of AMA, can induce an environment rich in oxidative species, increasing superoxide and reducing bioavailable nitric oxide in human cells.

Social influences on unconscious plagiarism and anti-plagiarism.

People are more likely to unconsciously plagiarise ideas from a same-sex partner than a different-sex partner, and more likely to unconsciously plagiarise if recalling alone rather than in the presence of their partner [Macrae, C. N., Bodenhausen, G.

The importance of internal facial features in learning new faces.

For familiar faces, the internal features (eyes, nose, and mouth) are known to be differentially salient for recognition compared to external features such as hairstyle. Two experiments are reported that investigate how this internal feature advantage accrues as a face becomes familiar. In Experiment 1, we tested the contribution of internal and external features to the ability to generalize from a single studied photograph to different views of the same face.

Motion as a cue to face recognition: evidence from congenital prosopagnosia.

Congenital prosopagnosia is a condition that, present from an early age, makes it difficult for an individual to recognise someone from his or her face. Typically, research into prosopagnosia has employed static images that do not contain the extra information we can obtain from moving faces and, as a result, very little is known about the role of facial motion for identity processing in prosopagnosia. Two experiments comparing the performance of four congenital prosopagnosics with that of age matched and younger controls on their ability to learn and recognise (Experiment 1) and match (Experiment 2) novel faces are reported.

Is overall similarity classification less effortful than single-dimension classification?

It is sometimes argued that the implementation of an overall similarity classification is less effortful than the implementation of a single-dimension classification. In the current article, we argue that the evidence securely in support of this view is limited, and report additional evidence in support of the opposite proposition--overall similarity classification is more effortful than single-dimension classification. Using a match-to-standards procedure, Experiments 1A, 1B and 2 demonstrate that concurrent load reduces the prevalence of overall similarity classification, and that this effect is robust to changes in the concurrent load task employed, the level of time pressure experienced, and the short-term memory requirements of the classification task.

The Shaping of the Face Space in Early Infancy: Becoming a Native Face Processor.

Face perception remains one of the most intensively researched areas in psychology and allied disciplines, and there has been much debate regarding the early origins and experiential determinants of face processing. This article reviews studies, the majority of which have appeared in the past decade, that discuss possible mechanisms underlying face perception at birth and document the prominent role of experience in shaping infants' face-processing abilities. In the first months of life, infants develop a preference for female and own-race faces and become better able to recognize and categorize own-race and own-species faces.

Covert detection of attractiveness among the neurologically intact: evidence from skin-conductance responses.

Several studies have shown that participants, without a deficit in face recognition, give an increased skin conductance response (SCR) to familiar faces when presented subliminally, hence suggesting covert recognition of these faces. In the experiment presented here we manipulated familiarity and attractiveness and tested whether participants distinguished between faces for these variables when presented too fast to allow conscious recognition. Three sets of faces were presented: famous attractive; unfamiliar attractive; and unfamiliar less attractive.

Processes of overall similarity sorting in free classification.

The processes of overall similarity sorting were investigated in 5 free classification experiments. Experiments 1 and 2 demonstrated that increasing time pressure can reduce the likelihood of overall similarity categorization. Experiment 3 showed that a concurrent load also reduced overall similarity sorting.

Learning faces from photographs.

Previous studies examining face learning have mostly used only a single exposure to 1 image of each of the faces to be learned. However, in daily life, faces are usually learned from multiple encounters. These 6 experiments examined the effects on face learning of repeated exposures to single or multiple images of a face.