Publications by authors named "Christopher Ledbetter"
Acupuncture has been widely studied, and theories regarding its analgesic mechanism of action have been proposed. It has been used for procedural analgesia; however, no reports of its use in urologic surgery have been reported. In this case report, we demonstrate how acupuncture can be used as an alternative to general anesthesia for transurethral resection of bladder tumor (TURBT).
View Article and Find Full Text PDFAndrogen receptor (AR) mediates the growth of prostate cancer throughout its course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-resistant disease. AR stabilization by androgens makes it distinct from other steroid receptors, which are typically ubiquitinated and degraded by proteasomes after ligand binding. Thus, targeting AR in advanced prostate cancer requires the development of agents that can sustainably degrade variant isoforms for effective therapy.
View Article and Find Full Text PDFArticle Synopsis
- Chromosome 15q11-q13.1 duplication is a common genetic variation linked to autism spectrum disorder (ASD), mostly inherited from the mother, and often results in ASD.* -
- The study investigates a family with a unique maternal duplication and somatic mosaicism, where the mother shows mild ASD and has a rare case of unilateral renal carcinoma, along with congenital anomalies.* -
- The research findings indicate that the mother has varying degrees of the duplication in different tissues and suggest a potential growth advantage linked to this specific duplication in her case, which may not apply broadly to others with the same genetic variation.*
Purpose: The purpose of this study is to investigate national trends in hospitalization from indwelling urinary catheters complications from 2001 to 2010.
Materials And Methods: The Healthcare Utilization Project Nationwide Inpatient Sample database was analyzed for this study. We examine hospitalization rates, patient demographics, hospital stays, insurance provider, hospital type, geographic location, and septicemia rates of patients hospitalized for indwelling urinary catheter complications from 2001 to 2010.