Publications by authors named "Christopher LePhong"
The incidence of cervical lymphadenopathy due to nontuberculous mycobacteria is rising in the pediatric population. Our goal with this study was to review the number of pediatric patients with granulomatous cervical adenitis and determine the incidence of identification of a specific organism as both healthcare providers and parents are interested in identifying the causative pathogen. A retrospective chart review was conducted of patients at a high-volume tertiary care children's hospital between 2017 and 2023.
View Article and Find Full Text PDFParaneoplastic presentations are often the initial presenting symptom of a malignant process. A 15-year-old female presented with a progressively growing, sclerotic lesion of the neck restricting the range of motion. She was found to have bilateral ovarian tumors that proved to be diffuse large B-cell lymphoma (DLBCL).
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- Pediatric invasive fungal rhinosinusitis (IFS) mainly affects immunocompromised children, with this study analyzing factors that influence survival rates among affected patients.
- A review of 18 children revealed a mean age of 9.8 years, most notably experiencing neutropenia and undergoing multiple surgeries to manage conditions like mucormycosis and aspergillosis.
- Positive prognostic factors for survival included extensive surgical procedures and multiple antifungal treatments, while negative indicators were altered mental status and serious complications, emphasizing the need for early diagnosis and aggressive treatment strategies.
Background: With advent of personalized medicine, precise classification of malignant tumors becomes essential. Squamous cell carcinoma (SCC) is rarely found in serous effusions and has morphologic and immunohistochemical (IHC) overlap with other neoplasms.
Methods: 17-year review identified 49 fluids from 26 patients where SCC was recognized.
Since pancreatic cancer is a lethal disease, developing prevention strategies is an important goal. We determined whether calorie restriction would prevent the development and delay progression of pancreatic intraepithelial neoplasms to pancreatic ductal adenocarcinoma (PDA) in LSL-KrasG12D/+; Pdx-1/Cre mice that develop all the precursor lesions that progress to PDA. Eight-week-old LSL-KrasG12D; Pdx-1/Cre mice were assigned to three groups: (1) ad libitum (AL) fed the AIN93M diet or (2) intermittently calorie restricted (ICR) a modified AIN93M at 50% of AL intake followed by one week intervals at 100% of AL intake, or (3) chronically calorie restricted (CCR) an AIN93M diet at 75% of AL intake.
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