Publications by authors named "Christopher Ld McMillan"
Elevated BMI reduces the humoral response to SARS-CoV-2 infection.
Clin Transl Immunology
December 2023
Article Synopsis
- * Methods: Blood samples were collected from individuals who had recovered from SARS-CoV-2 at 3 and 13 months post-infection, as well as from vaccinated individuals at 5 months post-vaccination, with a focus on comparing individuals based on BMI levels.
- * Results: Higher BMI is linked to reduced antibody responses following infection but not significantly after vaccination, highlighting the need for vaccination in individuals with a higher BMI for better immune protection.
Article Synopsis
- The study focuses on developing an effective SARS-CoV-2 vaccine using a prefusion-stabilized spike protein, Sclamp, combined with the adjuvant MF59 'MF59C.1'.
- Researchers produced and screened a panel of recombinant Sclamp proteins, assessing their structure and effectiveness through various animal studies.
- The results showed that the Sclamp vaccine generates strong immune responses, effectively reduces viral loads, and protects against lung disease in animal models, while being suitable for large-scale manufacturing.