Identification of natural antiviral drug candidates against Tilapia Lake Virus: Computational drug design approaches.

Tilapia Lake Virus (TiLV) is a disease that affects tilapia fish, causing a high rate of sudden death at any stage in their life cycle. Unfortunately, there are currently no effective antiviral drugs or vaccines to prevent or control the progression of this disease. Researchers have discovered that the CRM1 protein plays a critical function in the development and spreading of animal viruses.

Coastal aquaculture in Bangladesh: Sundarbans's role against climate change.

The Sundarbans, a natural shield on earth, is one and only place that has many noteworthy environmental and geographical values with breathtaking natural beauties. Near the Sundarbans area, proliferation of aquaculture in this delta contributes appreciably to the national economy. Although aquaculture has become a means of daily livelihood, this sector is nevertheless threatened by a complex of climate change impacts.

Initial experience with a continuous mechanical aspiration system for thrombus removal before percutaneous coronary intervention.

Objectives: Here we investigate the safety and efficacy of a continuous mechanical aspiration system when used before percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS).

Background: Historically, trials of routine manual aspiration thrombectomy in ACS patients have reported mixed results. This may be due to the technical limitations of manual aspiration, which suffers from decreasing vacuum power as aspiration is performed.

Single and Multi-Strain Probiotics Supplementation in Commercially Prominent Finfish Aquaculture: Review of the Current Knowledge.

The Nile tilapia , Atlantic salmon , rainbow trout , olive flounder , common carp , grass carp and rohu carp are farmed commercially worldwide. Production of these important finfishes is rapidly expanding, and intensive culture practices can lead to stress in fish, often reducing resistance to infectious diseases. Antibiotics and other drugs are routinely used for the treatment of diseases and sometimes applied preventatively to combat microbial pathogens.

Determination of the Most Efficient Household Technique for the Reduction of Pesticide Residues from Raw Fish Muscles.

Substantial quantities of pesticides are routinely applied to enhance agricultural crop production. Pesticides used in this way continuously accumulate in the environment and in foods. Harvested crops contain pesticide residues at various concentrations, with potential harmful impacts on human health.

Determination of Median Lethal Concentration (LC) for Endosulfan, Heptachlor and Dieldrin Pesticides to African Catfish, and Their Impact on Its Behavioral Patterns and Histopathological Responses.

Pesticides such as endosulfan, heptachlor and dieldrin persist in aquatic environments as a result of their resistance to biodegradation. However, there is no adequate information about the toxicity of endosulfan, heptachlor and dieldrin to the aquatic organism, African catfish ()-a high valued widely distributed commercially interesting species. The current experiment was performed with the aim to determine the median lethal concentration (LC) of endosulfan, heptachlor and dieldrin to African catfish (); their behavioral abnormalities and histopathological alterations in several vital organs.

Antiviral peptides from aquatic organisms: Functionality and potential inhibitory effect on SARS-CoV-2.

Several antiviral peptides (AVPs) from aquatic organisms have been effective in interfering with the actions of infectious viruses, such as Human Immunodeficiency Virus-1 and Herpes Simplex Virus-1 and 2. AVPs are able to block viral attachment or entry into host cells, inhibit internal fusion or replication events by suppressing viral gene transcription, and prevent viral infections by modulating host immunity. Therefore, as promising therapeutics, the potential of aquatic AVPs for use against the COVID-19 pandemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is considered.

A Revisit to the Research Updates of Drugs, Vaccines, and Bioinformatics Approaches in Combating COVID-19 Pandemic.

A new strain of coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for the coronavirus disease 2019 (COVID-19) pandemic was first detected in the city of Wuhan in Hubei province, China in late December 2019. To date, more than 1 million deaths and nearly 57 million confirmed cases have been recorded across 220 countries due to COVID-19, which is the greatest threat to global public health in our time. Although SARS-CoV-2 is genetically similar to other coronaviruses, i.

Micronutrient Adequacy in the Diet of Reproductive-Aged Adolescent Girls and Adult Women in Rural Bangladesh.

Micronutrient deficiencies remain a serious nutritional concern in Bangladesh, especially among rural women of reproductive age (WRA). This study assesses the diet quality of reproductive-aged adolescent girls and adult women (referred to together as WRA in this study), including socio-demographic factors associated with their diet quality. The diet quality of adolescent girls was compared with that of adult women to assess which group was most at risk.

Profiling the Neoplasm Microenvironment of Silica Nanomaterial-Derived Scaffolds of Single, 2-, and 3-Composite Systems.

The challenges with scaffold profiling of cell-based assay includes accelerated cancer cell proliferation, induced scaffold toxicity, and identifying irrelevant cancer cell-based assays in batch assessments. This study investigates profiling carcinoma of breast cancer cells of MCF-7 model systems using silica nanoparticles scaffold sourced from synthetic materials and plant extracts. Herein, the engineered tissue scaffolds were used to create temporary structures for cancer cell attachments, differentiation, and subsequently to assess the metabolic activity of the cancer cell colonies.

Batch Effect Adjustment to Lower the Drug Attrition Rate of MCF-7 Breast Cancer Cells Exposed to Silica Nanomaterial-Derived Scaffolds.

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Combating Antibiotic-Resistant Gram-Negative Bacteria Strains with Tetracycline-Conjugated Carbon Nanoparticles.

Nontoxic carbon nanoparticle samples prepared by both bottom-up and top-down approaches do not inhibit Gram-negative bacterial growth, indicating excellent biocompatibilities. However, cell growth inhibitory efficacies increase considerably when the carbon nanoparticles are conjugated with the antibiotic tetracycline. In tetracycline-resistant bacteria, these efficacies can approach tenfold higher activities when compared to tetracycline alone.

Mucosal immune response of Nile tilapia Oreochromis niloticus during Gyrodactylus cichlidarum infection.

Monogenean Gyrodactylus cichlidarum can cause severe mortality of Nile tilapia (Oreochromis niloticus) fry. To date, reports about mucosal immunity of O. niloticus against this parasite have been rare.

Cancer biomarker profiling using nanozyme containing iron oxide loaded with gold particles.

Nanozymes are nanomaterials with intrinsic magnetism and superparamagnetic properties. In the presence of an external magnet, nanozyme particles aggregate and redisperse without a foreign attraction. We evaluated the performances of nanozyme by changing the biosensing platforms and substituting other biological variants for a complete cancer assay detection.

The Effect of Thermal Treatment on the Hydrogen-Storage Properties of PIM-1.

There has been recent interest in polymers of intrinsic microporosity (PIMs) for solid-state hydrogen-storage materials; however, the gas-sorption properties and conditions for hydrogen uptake are relatively unexplored. PIM-1 has been synthesised using the condensation reaction between 3,3,3,3-tetramethyl-1,1-spirobisindane-5,5,6,6-tetraol and 2,3,5,6-tetrafluorophthalonitrile as precursors. The synthesised PIM-1 was annealed at different temperatures for varying times and then characterised for hydrogen uptake at both ambient and cryogenic temperatures.

Improving the Gas-Separation Properties of PVAc-Zeolite 4A Mixed-Matrix Membranes through Nano-Sizing and Silanation of the Zeolite.

Mixed-matrix membranes containing synthesised nano-sized zeolite 4A and PVAc were fabricated to investigate the effect of zeolite loading on membrane morphology, polymer-filler interaction, thermal stability and gas separation properties. SEM studies revealed that, although the membranes with 40 wt % nano-sized zeolite particles were distributed uniformly through the polymer matrix without voids, the membranes with 15 wt % zeolite loading showed agglomeration. With increasing zeolite content, the thermal stability improved, the permeability decreased and the selectivity increased.

Generating Oxygen Vacancies in MnO Hexagonal Sheets for Ultralong Life Lithium Storage with High Capacity.

The polar surface of (001) wurtzite-structured MnO possesses substantial electrostatic instabilities that facilitate a wurtzite to graphene-like sheet transformation during the lithiation/delithiation process when used in battery technologies. This transformation results in cycle instability and loss of cell efficiency. In this work, we synthesized MnO hexagonal sheets (HSs) possessing abundant oxygen vacancy defects (MnO-Vo HSs) by pyrolyzing and reducing MnCO HSs under an atmosphere of Ar/H.

Coordination of Atomic Co-Pt Coupling Species at Carbon Defects as Active Sites for Oxygen Reduction Reaction.

Platinum (Pt) is the state-of-the-art catalyst for oxygen reduction reaction (ORR), but its high cost and scarcity limit its large-scale use. However, if the usage of Pt reduces to a sufficiently low level, this critical barrier may be overcome. Atomically dispersed metal catalysts with high activity and high atom efficiency have the possibility to achieve this goal.

Expression of immune-related genes of Nile tilapia Oreochromis niloticus after Gyrodactylus cichlidarum and Cichlidogyrus sclerosus infections demonstrating immunosupression in coinfection.

Gyrodactylus cichlidarum and Cichlidogyrus sclerosus, two monogenean ectoparasite species commonly found on the body surface and gills of Nile tilapia (Oreochromis niloticus) respectively, inflicted considerable economic losses in intensive tilapia farming. In order to explore the immune response of tilapia against these two species of monogeneans, expression patterns of five immune-related genes were studied after singular G. cichlidarum or C.