Synthesis of 5-Alkyl- and 5-Phenylamino-Substituted Azothiazole Dyes with Solvatochromic and DNA-Binding Properties.

A series of new 5-mono- and 5,5'-bisamino-substituted azothiazole derivatives was synthesized from the readily available diethyl azothiazole-4,4'-dicarboxylate. This reaction most likely comprises an initial Michael-type addition by the respective primary alkyl and aromatic amines at the carbon atom C5 of the substrate. Subsequently, the resulting intermediates are readily oxidized by molecular oxygen to afford the amino-substituted azothiazole derivatives.

Plasma-Based Ambient Desorption/Ionization Mass Spectrometry for the Analysis of Liquid Crystals Employed in Display Devices.

Liquid-crystal displays (LCDs) are the most frequently used display technology worldwide these days. Due to the rather complex manufacturing process and purity requirements for the chemicals used, quality control and display failure analysis are important analytical tasks. Currently, the state-of-the-art techniques (e.

Fast screening and quantitative mass spectral imaging of thin-layer chromatography plates with flowing atmospheric-pressure afterglow high-resolution mass spectrometry.

Thin-layer chromatography (TLC) was interfaced to high-resolution mass spectrometry (MS) using a flowing atmospheric-pressure afterglow (FAPA) ambient desorption/ionization source. The influence of different TLC stationary phases on the mass spectral signal response and mass spectral image quality in FAPA-MS was carefully investigated. Specifically, a mixture of selected analgesics (acetaminophen), alkaloids (nicotine and caffeine), and steroids (cortisone) was deposited on different stationary phases (silica plates, RP-modified silica plates, CN-modified silica plates, DIOL-modified silica plates, and NH-modified silica plates), and TLC plates with different thickness (100, 200, 250, 500, 1000, 2000 μm) of the stationary phase.

Decomposition of PO in DMSO.

Intermediate states of degradation of phosphorus pentoxide in dimethyl sulfoxide (DMSO), also known as Onodera reagent, are studied. We found that DMSO is not dissolving PO, but rather reacting with it. A rather complex mixture of phosphate species is formed, many with ester functions.

Multiple liquid chromatography separations and nanoESI-ion trap detection of plasma proteins in search of stroke biomarkers: A pilot study.

Stroke is the most common cause of morbidity and death in the Western world, following ischemic heart disease and cancer. Stroke can be of two types, ischemic or hemorrhagic, with ischemic stroke accounting for approximately 85% of the total number of strokes. Well-recognized environmental risk factors for stroke include hypertension, smoking, diabetes mellitus, atrial fibrillation, and atherosclerosis.