Publications by authors named "Christopher Kim-Ming Hui"
Imaging Profile of the COVID-19 Infection: Radiologic Findings and Literature Review.
Radiol Cardiothorac Imaging
February 2020
Article Synopsis
- The study analyzed 21 COVID-19 cases from two Chinese centers, focusing on CT and chest radiographic findings, with follow-up imaging for five patients.
- The results indicated that ground-glass opacification was the most common imaging pattern, with no pleural effusions or lymphadenopathy observed, and showed how CT scans are more sensitive than standard chest X-rays in detecting these changes.
- The findings from Shenzhen and Hong Kong were consistent with previous studies, confirming that ground-glass opacification, sometimes accompanied by consolidation, is the primary pulmonary manifestation of COVID-19.
Article Synopsis
- * A study investigated a family of six, five of whom were infected after traveling to Wuhan, with one additional member contracting the virus through contact, despite no direct exposure to the wet market.
- * The infected family members exhibited various symptoms like fever and respiratory issues, showing significant clinical signs, especially in older patients who had more severe symptoms and complications detected via imaging and blood tests.
Article Synopsis
- Lung innate immunity acts as the initial defense against allergens, pathogens, and pollutants, with cellular metabolism playing a crucial role in this process.
- Activation of innate immune cells leads to metabolic shifts, particularly increased glycolysis and fatty acid synthesis, which are essential for their inflammatory functions.
- Disruption of these metabolic pathways in lung diseases like asthma and COPD could hinder immune cell effectiveness, highlighting the potential for new therapies targeting metabolism, similar to ongoing cancer treatments.
Article Synopsis
- Endothelial dysfunction is linked to both obstructive sleep apnea (OSA) and tobacco smoking, but the combined effect of these conditions on vascular health is not well understood.
- A study involving 114 Chinese men found that the severity of OSA decreased endothelial function and that smoking history exacerbated this impairment, particularly in those with moderate-severe OSA.
- Key findings indicated that independent factors like the severity of hypoxia and smoking quantity were strong predictors of worsening endothelial function, highlighting the dangerous interaction between smoking and OSA.