Publications by authors named "Christopher Kawaja"
JCEM Case Rep
September 2024
Article Synopsis
- A case study discusses a patient with surgical confirmation of Cushing's disease (CD) who had significantly high cortisol levels but did not display typical symptoms associated with the condition.
- The investigation ruled out other causes of elevated ACTH and cortisol, and revealed reduced activity of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which plays a crucial role in regulating cortisol levels in cells.
- The findings suggest that impaired 11β-HSD1 may explain the absence of classic Cushing's features in patients with high cortisol, highlighting its importance in diagnosing such cases.
