Publications by authors named "Christopher Jeanes"
To investigate the symptoms of SARS-CoV-2 infection, their dynamics and their discriminatory power for the disease using longitudinally, prospectively collected information reported at the time of their occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was the predominant strain.
View Article and Find Full Text PDFSurgical site infection (SSI) is the most common complication of surgery, increasing healthcare costs and hospital stay. Chlorhexidine (CHX) and povidone-iodine (PVI) are used for skin antisepsis, minimising SSIs. There is concern that resistance to topical biocides may be emergeing, although the potential clinical implications remain unclear.
View Article and Find Full Text PDFBackground: The recombinant protein-based vaccine, NVX-CoV2373, demonstrated 89.7% efficacy against coronavirus disease 2019 (COVID-19) in a phase 3, randomized, observer-blinded, placebo-controlled trial in the United Kingdom. The protocol was amended to include a blinded crossover.
View Article and Find Full Text PDFArticle Synopsis
- The NVX-CoV2373 vaccine, developed by Novavax, demonstrated safety and a strong immune response in early studies, but further research was needed to confirm its efficacy and safety in a larger population.
- In a phase 3 trial with over 15,000 participants in the UK, adults received two doses of either the vaccine or a placebo, with results showing a vaccine efficacy of 89.7% against COVID-19 infections and no severe cases among those vaccinated.
- The vaccine appeared effective against variants, with high efficacy rates against the B.1.1.7 variant, and adverse reactions were generally mild, indicating a favorable safety profile.
Article Synopsis
- The traditional method for diagnosing bacterial lower respiratory infections (LRIs) is culture, which is slow and not very sensitive, highlighting the need for faster techniques.
- A new metagenomic method was developed that uses saponin to remove human DNA and nanopore sequencing to quickly identify pathogens in LRIs, achieving results in just 6 hours.
- This optimized approach showed high sensitivity (96.6%) and specificity (100%) after further analysis, offering a promising solution for rapid diagnosis and potentially reducing the unnecessary use of broad-spectrum antibiotics.
Diagnosing tuberculosis in the 21st century - Dawn of a genomics revolution?
Int J Mycobacteriol
December 2016
Tuberculosis (TB) ranks alongside HIV as the leading cause of death worldwide, killing 1.5million people in 2014. Traditional laboratory techniques do not provide sufficiently rapid results to inform clinicians on appropriate treatment, especially in the face of increasingly prevalent drug-resistant TB.
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