Publications by authors named "Christopher Jaicks"
Article Synopsis
- Altered RNA expression and retrotransposition of repetitive sequences play a significant role in the progression of colorectal cancer, particularly in cells with p53 mutations.
- The nucleoside reverse transcriptase inhibitor 3TC was shown to target these repeat elements effectively, resulting in clinical benefits for some patients in a phase II trial.
- The study highlights a new cancer treatment strategy by exploiting the viral-like behavior of repeat sequences, using NRTIs to induce DNA damage and activate immune responses against colorectal cancer.
Article Synopsis
- The study investigates how SARS-CoV-2 affects the lungs at different severity levels by analyzing autopsy samples from 24 patients who died from the virus.
- It identifies two categories of patients: those with high viral loads showing strong immune responses and specific macrophage types, and those with low viral loads exhibiting varied responses and signs of lung recovery.
- The research also highlights that the spatial distribution of the virus and immune responses within the lungs is heterogeneous, with different patterns of interferon response genes linked to virus presence.
The relationship of SARS-CoV-2 lung infection and severity of pulmonary disease is not fully understood. We analyzed autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter- and intra- patient heterogeneity of pulmonary virus infection. There was a spectrum of high and low virus cases that was associated with duration of disease and activation of interferon pathway genes.
View Article and Find Full Text PDF