Biodiversity impacts of the 2019-2020 Australian megafires.

With large wildfires becoming more frequent, we must rapidly learn how megafires impact biodiversity to prioritize mitigation and improve policy. A key challenge is to discover how interactions among fire-regime components, drought and land tenure shape wildfire impacts. The globally unprecedented 2019-2020 Australian megafires burnt more than 10 million hectares, prompting major investment in biodiversity monitoring.

Expression of E-cadherin by CD8 T cells promotes their invasion into biliary epithelial cells.

The presence of CD8 T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary cholangitis (PBC). Here, we characterise the mechanism of CD8 T cell invasion into BEC. CD8 T cells observed within BEC were large, eccentric, and expressed E-cadherin, CD103 and CD69.

Building capacity for estimating fire emissions from tropical peatlands; a worked example from Indonesia.

Tropical peatlands are globally significant in the terrestrial carbon cycle as they are comprised of a large forest carbon sink and a large peat carbon store-both of which can potentially be exchanged with the atmosphere on decadal time frames. Greenhouse gas emissions from fire-disturbance and development of tropical peatlands over the last few decades, and the potential for ongoing emissions, highlights the need for policy to slow or halt emissions and to activate mechanisms to sequester carbon through restoration of degraded peatlands. The UN REDD + scheme provides a means for developing countries to receive payments for avoided deforestation and forest degradation, but the steps to achieve REDD+ compliance are rigorous and the details required can be a barrier to activating benefits-especially for peatlands where repeated cycles of fire interrupt forest recovery and create a range of recovery classes.

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis.

ˆCCL24 is a pro-fibrotic, pro-inflammatory chemokine expressed in several chronic fibrotic diseases. In the liver, CCL24 plays a role in fibrosis and inflammation, and blocking CCL24 led to reduced liver injury in experimental models. We studied the role of CCL24 in primary sclerosing cholangitis (PSC) and evaluated the potential therapeutic effect of blocking CCL24 in this disease.

Tree mortality and carbon emission as a function of wildfire severity in south-eastern Australian temperate forests.

Disturbance trends over recent decades indicate that climate change is resulting in increased fire severity and extent in Australia's temperate Eucalyptus forests. As disturbance cycles become shorter and more severe, empirical measurements are required to identify potential change in forest carbon (C) stock and emissions. However, such estimates are rare in the literature.

The Contribution of Liver Sinusoidal Endothelial Cells to Clearance of Therapeutic Antibody.

Many chronic inflammatory diseases are treated by administration of "biological" therapies in terms of fully human and humanized monoclonal antibodies or Fc fusion proteins. These tools have widespread efficacy and are favored because they generally exhibit high specificity for target with a low toxicity. However, the design of clinically applicable humanized antibodies is complicated by the need to circumvent normal antibody clearance mechanisms to maintain therapeutic dosing, whilst avoiding development of off target antibody dependent cellular toxicity.

Effects of prescribed fire frequency on wildfire emissions and carbon sequestration in a fire adapted ecosystem using a comprehensive carbon model.

Prescribed fire to reduce forest fuels has been routinely applied to reduce wildfire risk in many parts of the world. It has also been proposed that prescribed fire can be used to mitigate greenhouse gas (GHG) emissions. Although prescribed fire creates emissions, if the treatment also decreases the incidence of subsequent wildfires, it is possible for the net outcome to be an emissions decline.

Carbon balance of tropical peat forests at different fire history and implications for carbon emissions.

Accurate assessment of tropical peat forest carbon stocks and impact of fires on carbon pools is required to determine the magnitude of emissions to the atmosphere and to support emissions reduction policies. We assessed total aboveground carbon (AGC) in biomass pools including trees, shrubs, deadwood, litter and char, and peat carbon to develop empirical estimates of peat swamp forest carbon stocks in response to fire and disturbance. In contrast to the common assumption that peat fires combust all AGC, we observed that about half of undisturbed forest AGC, equivalent to about 70 Mg C ha, remains after one or two recent fires - mainly in dead trees, woody debris and pyrogenic carbon.

Vascular Adhesion Protein-1 Determines the Cellular Properties of Endometrial Pericytes.

Vascular adhesion protein-1 (VAP-1) is an inflammation-inducible adhesion molecule and a primary amine oxidase involved in immune cell trafficking. Leukocyte extravasation into tissues is mediated by adhesion molecules expressed on endothelial cells and pericytes. Pericytes play a major role in the angiogenesis and vascularization of cycling endometrium.

Identifying and addressing knowledge gaps for improving greenhouse gas emissions estimates from tropical peat forest fires.

Tropical peatlands are areas of high carbon density that are important in biosphere-atmosphere interactions. Drainage and burning of tropical peatlands releases about 5% of global greenhouse gas (GHG) emissions, yet there is great uncertainty in these estimates. Our comprehensive literature review of parameters required to calculate GHG emissions from burnt peat forests, following the international guidelines, revealed many gaps in knowledge of carbon pools and few recent supporting studies.

Defining Myocardial Abnormalities Across the Stages of Chronic Kidney Disease: A Cardiac Magnetic Resonance Imaging Study.

Objectives: A proof of concept cross-sectional study investigating changes in myocardial abnormalities across stages of chronic kidney disease (CKD). Characterizing noninvasive markers of myocardial fibrosis on cardiac magnetic resonance, echocardiography, and correlating with biomarkers of fibrosis, myocardial injury, and functional correlates including exercise tolerance.

Background: CKD is associated with an increased risk of cardiovascular death.

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure.

Acetaminophen (APAP) is the main cause of acute liver failure in the West. Specific efficacious therapies for acute liver failure (ALF) are limited and time-dependent. The mechanisms that drive irreversible acute liver failure remain poorly characterized.

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis.

Infectious complications in patients with cirrhosis frequently initiate episodes of decompensation and substantially contribute to the high mortality. Mechanisms of the underlying immuneparesis remain underexplored. TAM receptors (TYRO3/AXL/MERTK) are important inhibitors of innate immune responses.

Effect of thinning and burning fuel reduction treatments on forest carbon and bushfire fuel hazard in Eucalyptus sieberi forests of South-Eastern Australia.

More frequent hot and windy weather in fire prone forested landscapes requires that a full suite of fuel reduction measures be investigated for effectiveness in fuel hazard reduction, environmental impact and carbon (C) outcomes. Although prescribed fire and thinning are routinely applied in forests of North America to reduce fuel loads, there are few detailed studies from Australia. We report the impacts of fuel reduction treatments including burning, mechanical thinning and the combination of both on forest C and fuel hazard in open forests dominated by Eucalyptus sieberi in south-eastern Australia.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Antiplatelet therapy (APT; aspirin/clopidogrel, ticagrelor) but not nonsteroidal anti-inflammatory drug (NSAID) treatment with sulindac prevented NASH and subsequent HCC development.

Novel Targets in the Immune Microenvironment of the Hepatic Sinusoids for Treating Liver Diseases.

Immune dysregulation and accumulation of leukocytes is a hallmark of adult chronic liver diseases. Progressive hepatic inflammation can lead to fibrosis and cirrhosis with a high risk of liver failure or hepatocellular cancer (HCC). Recent advances have been made in the treatment of liver disease including the development of highly effective antiviral therapy for hepatitis C and the potential of immunotherapy for HCC.

Fire intensity effects on post-fire fuel recovery in Eucalyptus open forests of south-eastern Australia.

This is a study of the re-accumulation of bushfire fuels following both prescribed fire of low fireline intensity (<700 kW m) and wildfire of high intensity (>10,000 kW m) in Australian Eucalyptus open forests of differing annual rainfall. Repeated measurements over 5 to 7 years of litter, elevated fuels, coarse woody debris, and bark revealed more rapid fuel recovery in higher rainfall forests compared with lower rainfall forests, following prescribed fire. In prescribed-burnt forests with mean annual rainfall 900-950 mm all fuel categories recovered to very high within seven years, with elevated fuels exceeding pre-fire loads by up to 200%.

Aboveground carbon of community-managed Chirpine ( Sarg.) forests of Nepal based on stand types and geographic aspects.

On a global scale, about 15.5% of forests are administered through community-based forestry programs that offer the opportunity for enhanced carbon sequestration while maintaining the supply of more traditional goods and services such as cooking fuels, animal fodder and bedding. A challenge in community forest (CF) management is to realize their carbon value without compromising their role in the provision of these traditional goods and services.

The Reactive Oxygen Species-Mitophagy Signaling Pathway Regulates Liver Endothelial Cell Survival During Ischemia/Reperfusion Injury.

Ischemia/reperfusion injury (IRI) is the main cause of complications following liver transplantation. Reactive oxygen species (ROS) were thought to be the main regulators of IRI. However, recent studies demonstrate that ROS activate the cytoprotective mechanism of autophagy promoting cell survival.

A data - Model fusion methodology for mapping bushfire fuels for smoke emissions forecasting in forested landscapes of south-eastern Australia.

The increasing regional and global impact of wildfires on the environment, and particularly on the human population, is becoming a focus of the research community. Both fire behaviour and smoke dispersion models are now underpinning strategic and tactical fire management by many government agencies and therefore model accuracy at regional and local scales is increasingly important. This demands accuracy of all the components of the model systems, biomass fuel loads being among the more significant.

Importance of disturbance history on net primary productivity in the world's most productive forests and implications for the global carbon cycle.

Analysis of growth and biomass turnover in natural forests of Eucalyptus regnans, the world's tallest angiosperm, reveals it is also the world's most productive forest type, with fire disturbance an important mediator of net primary productivity (NPP). A comprehensive empirical database was used to calculate the averaged temporal pattern of NPP from regeneration to 250 years age. NPP peaks at 23.

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease.

Nonalcoholic fatty liver disease (NAFLD) is a common disease, closely associated with obesity and insulin resistance. We investigated the presence of a subset of myeloid cells associated with metabolic disturbance in the liver of patients with NAFLD and a murine model of obesity-induced liver disease. Gene and protein expression in liver and serum was investigated with RT-PCR or ELISA and correlated to clinical disease.

Geometric confinement is required for recovery and maintenance of chondrocyte phenotype in alginate.

Human articular chondrocytes lose their native phenotype when expanded in traditional monolayer cultures. As a consequence, hydrogel encapsulation has been investigated as a means to maintain the natural phenotype. Alginate has been widely used for cartilage engineering as it has been shown to enable the recovery of a native collagen type II expressing chondrocyte phenotype.

CD14 CD15 HLA-DR myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure.

Objective: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14HLA-DR myeloid-derived suppressor cells (M-MDSCs) have recently been identified to quell antimicrobial responses in immune-mediated diseases. We sought to delineate the function and derivation of M-MDSC in patients with ACLF, and explore potential targets to augment antimicrobial responses.