Publications by authors named "Christopher J Testa"
An automated modular assembly line for drugs in a miniaturized plant.
Chem Commun (Camb)
January 2020
We report here a fully automated, end-to-end, integrated continuous manufacturing process for a small-molecule generic medication with built-in quality assurance. The entire process fits into a box of 30.7 m2 modular footprint and a total residence time of less than 30 h, with a throughput up to 40.
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- The yeast ARL1 gene is associated with a guanine-nucleotide binding protein from the Arf-like family and interacts genetically with CCZ1.
- An arl1 Delta ccz1 Delta double mutant is viable but shows slower growth and increased sensitivity to substances like caffeine and zinc, alongside more severe issues in vacuolar protein sorting.
- Overexpressing either ARL1 or CCZ1 does not alleviate the mutant phenotypes of the other, indicating that both genes play independent roles in ion homeostasis and protein sorting.